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I-TASSER results for job id S802034

(Click on S802034_results.tar.bz2 to download the tarball file including all modeling results listed on this page. Click on Annotation of I-TASSER Output to read the instructions for how to interpret the results on this page. Model results are kept on the server for 60 days, there is no way to retrieve the modeling data older than 2 months)

Submitted Sequence in FASTA format

>protein
MASEEMEGLCPLPEVTGIKVEPSVSIGSTEDASSQNTMGIKFILPNRFDMNVCSRFVKSL
NEEDSKNIQDQVNSDLEVASVLFKAECNIQTSPSPGIQVRHVYTPSTTKHFSPIKQSTTL
TNKHRGNEVSSTPLLVHSLSIHQLAAQGEMVFLASRIEQESVINLQDEEGFTPLMWAAAH
GQIAVVEFLLQSGADPHLLAKGRESALSLACSKGYTDIVRMLIDCGVDVNEYDWNGGAPL
LYAVHGNHVRCVEILLESGSDPTMESDSGFNAMDMAVAMGHRNVQQVLEAHLLKLLQGIK
E

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MASEEMEGLCPLPEVTGIKVEPSVSIGSTEDASSQNTMGIKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIQTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSSTPLLVHSLSIHQLAAQGEMVFLASRIEQESVINLQDEEGFTPLMWAAAHGQIAVVEFLLQSGADPHLLAKGRESALSLACSKGYTDIVRMLIDCGVDVNEYDWNGGAPLLYAVHGNHVRCVEILLESGSDPTMESDSGFNAMDMAVAMGHRNVQQVLEAHLLKLLQGIKE
Prediction	CCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
Conf.Score	9775578888398665189998997596488883983789999984988779999974557899748999987689999999987999888899998889999999689999999996537875677689880132322799999877899999999779998889998988899999867499999999879998988999988899999859399999999869998899999989999999809099999999879999998998988999999878499999999869997845789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MASEEMEGLCPLPEVTGIKVEPSVSIGSTEDASSQNTMGIKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIQTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSSTPLLVHSLSIHQLAAQGEMVFLASRIEQESVINLQDEEGFTPLMWAAAHGQIAVVEFLLQSGADPHLLAKGRESALSLACSKGYTDIVRMLIDCGVDVNEYDWNGGAPLLYAVHGNHVRCVEILLESGSDPTMESDSGFNAMDMAVAMGHRNVQQVLEAHLLKLLQGIKE
Prediction	7435415411313633514032017300231056632200110024503040043016432523020010034322300411063404144636402000000000443011003102630334342642200021023000100343123001100634042244264220020000232022004110633041344364330000100343111002030634031144164120000000343122004120634043546164330020000333133004110634053356468
	Values range from 0 (buried residue) to 9 (highly exposed residue)

Predicted normalized B-factor

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

(I-TASSER modeling starts from the structure templates identified by LOMETS from the PDB library. LOMETS is a meta-server threading approach containing multiple threading programs, where each threading program can generate tens of thousands of template alignments. I-TASSER only uses the templates of the highest significance in the threading alignments, the significance of which are measured by the Z-score, i.e. the difference between the raw and average scores in the unit of standard deviation. The templates in this section are the 10 best templates selected from the LOMETS threading programs. Usually, one template of the highest Z-score is selected from each threading program, where the threading programs are sorted by the average performance in the large-scale benchmark test experiments.)

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Z-score

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 

Sec.Str
Seq

CCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
MASEEMEGLCPLPEVTGIKVEPSVSIGSTEDASSQNTMGIKFILPNRFDMNVCSRFVKSLNEEDSKNIQDQVNSDLEVASVLFKAECNIQTSPSPGIQVRHVYTPSTTKHFSPIKQSTTLTNKHRGNEVSSTPLLVHSLSIHQLAAQGEMVFLASRIEQESVINLQDEEGFTPLMWAAAHGQIAVVEFLLQSGADPHLLAKGRESALSLACSKGYTDIVRMLIDCGVDVNEYDWNGGAPLLYAVHGNHVRCVEILLESGSDPTMESDSGFNAMDMAVAMGHRNVQQVLEAHLLKLLQGIKE

1n11A

0.18

0.23

0.97

3.15

Download

VNAKAKDDQTPLHIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHN--NLDIVKLLLPRGSPHSPAWNGYT-------PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD

7dsyA

0.20

0.21

0.88

2.99

Download

--SLEEMLTQAVQEADIEQVRQLLERGADANFQEE-------------------------EWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITG--NVRLLQLLLPVEDVNECDVNGFTA-------FMEAAVYGRVEALRFLYENGADVNMHRKGGATALMDAAEKGHVGVVTILLHMKAEVDARDNMGRNALVYALDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLV

5vkq

0.19

0.25

1.00

0.82

Download

YTCQQMNRQSSVGWTPANLLANHARVDVFTEGRSALAAGYNKAFINSKSRVGRTALHLAAMNRKTPLHLAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYAHIAAEGGHADVALVRAGNKAGFTAVHSGMTPLHLAAFSGNENVVRLLLNSGVQVDAAIENGYNPLHLACFGGHMSVVGLLLSRSAELQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHLEVVKLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLMQE

7pty

0.13

0.24

1.00

0.74

Download

IEAKFDNDRSAMHAVAYKIARFLLKNQSDIELKDKNGFTPLHIAAEAGQAGFVKLLINHGATNLTPLHLATRSGFSKTVRNLLESNIKVNEKEDDGFTPLHTAVAIINESQEVAESLVENADLNIQDVNHMAPIHFAATPLHFAIYFKKEDAAKELLQDDINLTIVADGNLTVLHLAVSTGQINIIKELLKRGSNIEEKTGEGYTSLHIAAMRKEPEIAVVLIENGADIEARSADNLTPLHSAAKIGRKSTVLYLLEKGADIGAKTADGSTALHLAVSGRKMKTVETLLNKGANLKEYDNN

5et0A

0.17

0.23

0.94

2.96

Download

-GLLDSLDALPVHSGKLHCLRYLVEEVAPAVSRARNGATPAHDAAATGYLSCLQWLLTQGNSGATVLHLAARFGHPDVVKWLLYQGANSAITTDTGALPIHYAAAKG--DLPSLKLLVGHEGVNAQTNNGAT-------PLYLACQEGHLEVTKYLVQESADPHLRAQDGMTPLHAAAQMGHNPVLVWLVSFAVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAEIS-QDLWGGTPLHDAAENGELECCQILAVNGAGLDVRDHDGYTAADLAEFNGHTHCSRYLRTVQ-TLS-----

7pty

0.18

0.24

0.76

0.98

Download

----------------------------------------------------------------TPFHLAIINESQEVAESLVESNADLNIQDVNHMAPIHFAASMGSIKMLRYLISIKDVSINSTENNNWTPADGNLTVLHLAVSTGQINIIKELLKRGSNIEEKTGEGYTSLHIAAMRKEPEIAVVLIENGADIEARSADNLTPLHSAAKIGRKSTVLYLLEKGADIGAKTADGSTALHLAVSGRKMKTVETLLNKGANLKEYDNNKYLPIHKAIINDDLDMVRLFLEKD---------

6molA

0.23

0.26

0.96

4.94

Download

VNAQDAAGGTPLHEAARAGVEVLLKYGADVNAVDAAGGTPLHEAARAGHLEIVEVLLKYGADVNTPLHEAARAGHLEIVEVLLKYGADVNAVDAAGGTPLHEAARA--GHLEIVEVLLKGADVNAVDAAGGT-------PLHEAARAGHLEIVEVLLKYGADVNAVG----TPLHKAARAGHLEIVEVLLKYGADVNATDIWDATPLHLAALIGHLEIVEVLLKNGADVNASDITGTTPLHLAATMGHLEIVEVLLKYGADVNAYDLNGATPLHLAARMGHVEIVEVLLKYGADVNAQDKF

7ptxA

0.17

0.25

0.95

3.29

Download

NAKTKVKNWTPLLFKKFDVAQSLLQRNIDLAAATGNSQIVKTILNSGAVVD------QETANGFTALHLAIMNPNTETPQFLIAKGANINAKTNDGSTPLHF--AAALGKTNIFQLLMDKANIKAENLINQMPI-------HEAVVNGHLAIVKMLIEQDSSLNAKNMRDEYPFYLAAEKRYKDVFNYLESKGADVNEKNNDGNTLLHLFSINGEVEVVQFLIQNGADFRLRNKERKSFFDLAVEFGHAGIVGYAIEENKVDLQEPEDQCSPLQEAAAYAHLDLVKYFVQRGINPTAFNND

6molA

0.22

0.26

0.97

4.43

Download

VNASDITGTTPLHMGHLEIVEVLLKYGADVNAYDLNGATPLHLAARMGHVEIVEVLLKYGADGGTPLHEAARAGHLEIVEVLLKYGADVNAVDAAGGTPLHEAARA--GHLEIVEVLLKGADVNAVDAAGGT-------PLHEAARAGHLEIVEVLLKYGADVNAVDAAGGTPLHEAARAGHLEIVEVLLKYGADVNAVDAAGGTPLHEAARAGHLEIVEVLLKYGADVNATDIWDATPLHLAALIGHLEIVEVLLKNGADVNASDITGTTPLHLAATMGHLEIVEVLLKYGADVNAYDLN

3so8A

0.82

0.44

0.54

2.36

Download

----------------------------------------------------------------------------------------------------------------------------------------NSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGFTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNEYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESHLLKLLQN---

(a)	All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)	Rank of templates represents the top ten threading templates used by I-TASSER.
(c)	Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)	Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)	Cov represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)	Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)	Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)	The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
	1: MUSTER 2: SPARKS-X 3: HHSEARCH2 4: HHSEARCH I 5: Neff-PPAS 6: HHSEARCH 7: pGenTHREADER 8: PROSPECT2 9: SP3 10: FFAS03

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of a higher value signifies a model with a higher confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated; this is usually an indication that the models have a good quality because of the converged simulations.)

(By right-click on the images, you can export image file or change the configurations, e.g. modifying the background color or stopping the spin of your models)

Download Model 1 C-score=-0.19 (Read more about C-score) Estimated TM-score = 0.69±0.12 Estimated RMSD = 6.6±4.0Å	Download Model 2 C-score = -2.63	Download Model 3 C-score = -2.36	Download Model 4 C-score = -2.44	Download Model 5 C-score = -0.66

Proteins structurally close to the target in the PDB (as identified by TM-align)

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	Alignment
1	6molA	0.892	2.10	0.210	0.967	Download
2	1n11A	0.890	2.17	0.168	0.970	Download
3	5vkqA	0.886	2.35	0.138	0.987	Download
4	4rlvA	0.879	2.01	0.198	0.957	Download
5	7tw3G	0.871	2.39	0.167	0.970	Download
6	7ptxA	0.824	2.95	0.162	0.967	Download
7	7ptyA	0.804	3.22	0.154	0.970	Download
8	6m11a	0.797	3.10	0.130	0.947	Download
9	6skuA	0.790	3.22	0.098	0.954	Download
10	5et0A	0.789	3.21	0.148	0.937	Download

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COFACTOR and COACH

(This section reports biological annotations of the target protein by COFACTOR and COACH based on the I-TASSER structure prediction. While COFACTOR deduces protein functions (ligand-binding sites, EC and GO) using structure comparison and protein-protein networks, COACH is a meta-server approach that combines multiple function annotation results (on ligand-binding sites) from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	2	3b95B	PEPTIDE	Rep, Mult	171,175,176,179,202,204,209,212,233,242
2	0.09	3	3kndA	PEPTIDE	Rep, Mult	106,139,145,146,148,153,171,176,177,209
3	0.09	2	1wdyA	25A	Rep, Mult	93,97,102,105,134,136,167,169,171,176,179,180,200
4	0.06	2	2gl7D	PEPTIDE	Rep, Mult	56,59,61,63,66
5	0.06	2	1q1tC	PEPTIDE	Rep, Mult	98,102,104,105,106,136,139,142,143,146,177

	Download the residue-specific ligand binding probability, which is estimated by SVM.
	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.447	3b95B	0.677	2.30	0.210	0.741	2.1.1.43	229,249,259
2	0.212	2q1fA	0.494	5.88	0.090	0.801	4.2.2.21	NA
3	0.209	1ho8A	0.491	5.53	0.072	0.764	3.6.3.14	NA
4	0.199	1bf2A	0.459	6.34	0.045	0.781	3.2.1.68	NA
5	0.196	1f1sA	0.470	6.38	0.045	0.807	4.2.2.1	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Top 10 homologous GO templates in PDB
1	0.40	0.6724	2.18	0.17	0.73	2dvwA	GO:0005838 GO:0051437 GO:0043409 GO:0015629 GO:0000075 GO:0070682 GO:0006977 GO:0006915 GO:0005515 GO:0000502 GO:0045737 GO:0007253 GO:0030307 GO:0005634 GO:0008134 GO:0042981 GO:0051436 GO:0008540 GO:0016071 GO:0000122 GO:0031145 GO:0045111 GO:0032436 GO:0016070 GO:0000278 GO:0034641 GO:0043518 GO:0031398 GO:0000216 GO:0032088 GO:0005737 GO:0000084 GO:0043066 GO:0000082 GO:0016032 GO:0051439 GO:0006521 GO:0090201
2	0.34	0.8898	2.17	0.17	0.97	1n11A	GO:0005515
3	0.33	0.6764	2.28	0.18	0.75	3eu9A	GO:0005515
4	0.33	0.6852	2.37	0.21	0.75	3b7bA	GO:0005515
5	0.32	0.6734	2.47	0.18	0.75	1wg0A	GO:0070682 GO:0005634 GO:0005829 GO:0003674 GO:0005515 GO:0005838 GO:0006508
6	0.30	0.7399	2.73	0.18	0.85	1wdyA	GO:0005515
7	0.29	0.6104	2.48	0.08	0.69	2xaiD	GO:0005515 GO:0035556
8	0.29	0.7052	2.43	0.15	0.78	2fo1E	GO:0005515
9	0.26	0.6392	5.16	0.05	0.95	3gjxA	GO:0005654 GO:0034504 GO:0051028 GO:0042176 GO:0000776 GO:0005730 GO:0046825 GO:0005737 GO:0015031 GO:0005515 GO:0005634 GO:0030529 GO:0005642 GO:0003723 GO:0010824 GO:0009615 GO:0006810 GO:0008565 GO:0015030 GO:0006611 GO:0005488 GO:0006886
10	0.26	0.6387	5.16	0.09	0.96	1b3uA	GO:0000775 GO:0015630 GO:0005515 GO:0005739 GO:0006917 GO:0008380 GO:0042518 GO:0006461 GO:0005737 GO:0005829 GO:0030155 GO:0019932 GO:0030308 GO:0046982 GO:0006470 GO:0006672 GO:0006275 GO:0000278 GO:0005634 GO:0030111 GO:0000188 GO:0003823 GO:0005694 GO:0000086 GO:0000159 GO:0005625 GO:0040008 GO:0010033 GO:0007059 GO:0045595 GO:0008601 GO:0016020 GO:0006355 GO:0005488 GO:0042981 GO:0070262 GO:0004722

Consensus prediction of GO terms

Molecular Function GO:0008134

GO-Score 0.40

Biological Process GO:0070682 GO:0000122 GO:0051436 GO:0000084 GO:0045737 GO:0006977 GO:0031145 GO:0032088 GO:0000216 GO:0006521

GO-Score 0.59 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40 0.40

Cellular Component GO:0005634 GO:0015629 GO:0008540 GO:0045111 GO:0005829

GO-Score 0.59 0.40 0.40 0.40 0.32

(a) Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.

(b) TM-score is a measure of global structural similarity between query and template protein.

(c) RMSD^a is the RMSD between residues that are structurally aligned by TM-align.

(d) IDEN^a is the percentage sequence identity in the structurally aligned region.

(e) Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

(f) The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on S802034_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

Please cite the following articles when you use the I-TASSER server:

Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. Cell Reports Methods, 1: 100014 (2021).
Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017).
Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.