D-I-TASSER P19484-D1

D-I-TASSER results for P19484-D1

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>P19484 (476 residues)
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQ
SPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPA
ASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQM
PNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNH
NLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELEN
HSRRLEMTNKQLWLRIQELEMQARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEAL
MLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPG
HGSPFPSLSKKDLDLMLLDDSLLPLASDPLLSTMSPEASKASSRRSSFSMEEGDVL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQMPNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGHGSPFPSLSKKDLDLMLLDDSLLPLASDPLLSTMSPEASKASSRRSSFSMEEGDVL
Prediction	CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Confidence	98524678899999887666788887630356555556788777889998875688878888899964345666668987767643344542001134567766655566667888888788887776766678887666776322355666655543322344675422356798777788788886656678888887766556667778877765556774334421112011234629999999999999999997477767865456799999999999999999999999999999999999999999999998764313788888777785322455556788877788654456778888888766787777777789988877767666766566676666656655676778876544323555555224567778886423589756677877665445556679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQMPNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGHGSPFPSLSKKDLDLMLLDDSLLPLASDPLLSTMSPEASKASSRRSSFSMEEGDVL
Prediction	75334412110245445545444444554444444443444344444243311333343343442334324342324412423344334433443134434443233333444324333343232332222223444333432332243244343344422452242543243443434343322333432423446454444444444443245354444346442544545642253023003301530251054025002302456342310200420050043036225424524533540452054035215404432444424344344343443444334443344533443343444444443344334434343424141213312232214344344442432333233333232333433402200111020220010000002133144232310233444557
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of AttentionPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MASRIGLRMQLMREQAQQEEQRERMQQQAVMHYMQQQQQQQQQQLGGPPTPAINTPVHFQSPPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETYGNKFAAHISPAQGSPKPPPAASPGVRAGHVLSSSAGNSAPNSPMAMLHIGSNPERELDDVIDNIMRLDDVLGYINPEMQMPNTLPLSSSHLNVYSSDPQVTASLVGVTSSSCPADLTQKRELTDAESRALAKERQKKDNHNLIERRRRFNINDRIKELGMLIPKANDLDVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQLWLRIQELEMQARVHGLPTTSPSGMNMAELAQQVVKQELPSEEGPGEALMLGAEVPDPEPLPALPPQAPLPLPTQPPSPFHHLDFSHSLSFGGREDEGPPGYPEPLAPGHGSPFPSLSKKDLDLMLLDDSLLPLASDPLLSTMSPEASKASSRRSSFSMEEGDVL

1vt4I3

0.07

2.70

1.30

CEthreader

RMTLFRMVFLDFRFLEQKIRHDSTAWNASGSILNTLQQLKFYKPYICDNDPKYERLVNAILDFLPKIEENLICSKYTDLLRIALMAEDEAIFEEAHKQVQRGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-----------------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

5yfpE

0.09

0.08

3.08

1.08

SPARKS-K

ELKNLNEETLNKRQYFSEQVATQEVIHSENVIKLSKDLHTTLLTFDKLDDRLTNVTQVVS----------PLGDKLETAIKKKQNYIQSVELIRRYNDFYSMDIVEQLRLSKNWKLNLKSVKLMKNLLILSSKLETSSIPKTINTKLVIEKYSEMMENELLENFN---SAYRENNFT-KLNEIAIILNNFIQSFINQHDYFIFIKNVKFKEQLIDFENHSVIINDVETVIKNESKIVKRQLFIQRVFAQKIEPRFEVLLRNSLSISNL--------------AYVRILHGLFTLFGKFTKSLIDYFQLIDDSNQILSTTLEQCFADLFSHYLYDRSKYFGIEKRSLEAILVDMTSKFTVNYDKEINKRV-----LLDKYKEKLSTNTASDIDN-SPNSPANYSLNDVDSMLKCVVELIPNKAHLYILEILKIMFLGI-VDSYMEIALEVAYWKICKVDINKTAGVVNLNFLKFISM

1vt4I3

0.05

2.47

1.74

MapAlign

LHRSIVDHYNIPKTYFYSHIGHHLKNIEHPERMTLFRVFLDFRFLEQKIRHDSTAWNASGSILNTLQQLKFYKPYICDNDPKYERLVNAILDFLPKGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

4c7nB

0.45

0.05

1.41

3.40

HHsearch

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASAIVDYERKIQRIQQRVAELENTLKKLEHENRHLEQRAQELEQQIRAHAG----------------------------------------------------------------------------------------------------------------------------------------------------

1o0sA

0.06

2.62

0.90

CEthreader

-----------SVAHHEDVYSHNLPPMDEKEMALYKLYRPERVTPKKRSAELLKEPRLNKGMGFSLYERQYLGLHGLLPPAFMTQEQQAYRVITKLREQPNDLARYIQLDGLQDRNEKLFYRVVCDHVKELMPIVYTPTVGLACQNFGYIYRKPKGLYITINDN-SVSKIYQILSNWHEEDVRAIVVTDGERILGLGDLGAYGIGIPVGKLAKWCLPVLLDVGTNNMDLLNDPFYIGLRHKRVRGKDYDTLLDNFMKA--CTKKYGQKTLIQFEDFANPNAFRLLDKYQDKYTMFNDDIQGTASVIVAGLLTCTRVTKKLVSQEKYLFFGAGAASTGIVHQMQNEGISKEEACNRIYLMDIDGLVTKNRKEMNPRHVQFAKDMPETTSILEVIRAARPGALIGASTVRGAFNEEVIRAMAEINEFALSNPTSKAECTAEEAYTFTNGAALYASGSPFPNFELNGHTYKPGQGNNAY

6gmhQ

0.06

2.58

0.87

EigenThreader

GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGVEAMQAESCYQLARSFHVQYYYQATQFASSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDRLGNLGEAKKYFLASLDRAKAEAEHDEHNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQ-----EWGPGQKKFERILSDTYSMLALGNVWLQTLHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNA

6g1lA

0.76

0.13

3.57

0.93

FFAS-3D

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPDMRWNKGTILKASVDYIRKLQREQQRAKDLENRQKKLEHAN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------

5yfpA1

0.08

0.05

2.18

0.91

SPARKS-K

LTDINWSIEDDADSMIERIDLRLAETEYLFNQNLLSLQKIGPNIR----------------------------------PYEDKVNDECHRIIPTLSLFMSNFSNDIENVESQDNGLQVESANKKLLWNTLDELKTVSLDEISLNQLLECPIREKNLPWMENQLNLLLKAFQAIGSDG---------------NEVEYNLREISGLKQRLQFYEKVTKIFLNRIVEEMQKKFSNIRGQDISHDQMIRILTTLLIFSPLILFCKEISQKSY----------------------------QAIVENWNVSIQP-------------------------VYMELWTKKISQLQGIDTNDEKMNELSLSQLLNEWDTFRKERKTNDINPVFKNSFSLLTECLQ---------TMRQECIVYQNFVEVFFHISSKHNFEEYIKHFNDPDAP------------------------------

4iggA

0.11

0.05

1.82

0.74

CNFpred

--AVRQALQDLLSEYMGNAGRKER-----------------------------------------SDALNSAIDKMT-KKTRDLRRQLRKAVMDHVSDSFLTNVPLLVLIEAAKNGNEKEVKE-----------------------------YAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCP-------------------------QVINAALALAAKPQSKLAQENMDLFKE-QWEKQVRVLTDAVDDI------TSIDDFLAVSENHILEDVNKCVIAL--EKDVDGLDRTAGAIRGRAARVIHVVTSEM-----------------------------------------------------------------------------------------------------------------------------------------------------

6z2wE

0.06

0.03

1.30

0.50

DEthreader

---VDSKVQIKPACVEFGFGNSILDSGTKFDFNFQRIQKFVLTTHH--SKCFVRSFNKTERGTKNSFILEASVSIQ-------------------------------------------------------------------------------T-CFKTNNITRLTSWTVIGRCCHRLRIPIAWTLLLKLIDIFNSDDYSLRIMMTLQINMAPYLILLLLGNLLYIIPYINQIFAVLYLPDYLLIKLQDNLSSESWMHK--------SL-L-----ENHPLH---D--AEFKQNYSKTFIISTKYEKIKYSLKSLHDRWQHTAVDGKLEFYMVTPATSEDNLSK----------------------------------------------------------------------------------------------------------------------------------

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.4208

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of AttentionPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	6z2wE	0.33	6.82	0.055	0.517	model1_6z2wE.pdb.gz
2	6m04A	0.29	6.51	0.059	0.437	model1_6m04A.pdb.gz
3	5x6oC	0.29	6.97	0.045	0.458	model1_5x6oC.pdb.gz
4	2pffB	0.29	7.34	0.026	0.473	model1_2pffB.pdb.gz
5	6g2dC	0.28	7.65	0.024	0.471	model1_6g2dC.pdb.gz
6	6tedQ	0.28	6.18	0.092	0.410	model1_6tedQ.pdb.gz
7	6um1A	0.27	6.80	0.055	0.422	model1_6um1A.pdb.gz
8	6tgbA	0.27	6.79	0.036	0.431	model1_6tgbA.pdb.gz
9	4rlvA	0.27	6.06	0.053	0.397	model1_4rlvA.pdb.gz
10	6w1sI	0.27	6.60	0.025	0.410	model1_6w1sI.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:0003700	0.85	transcription factor activity, sequence-specific DNA binding
GO:1901363	0.79	heterocyclic compound binding
GO:0097159	0.79	organic cyclic compound binding
GO:0003676	0.78	nucleic acid binding
GO:0003677	0.75	DNA binding
GO:0000981	0.63	RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0044212	0.55	transcription regulatory region DNA binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0009987	0.80	cellular process
GO:0065007	0.77	biological regulation
GO:0050789	0.77	regulation of biological process
GO:0050794	0.76	regulation of cellular process
GO:0019222	0.74	regulation of metabolic process
GO:0080090	0.73	regulation of primary metabolic process
GO:0031323	0.73	regulation of cellular metabolic process
GO:0010468	0.73	regulation of gene expression
GO:0006355	0.72	regulation of transcription, DNA-templated
GO:0048518	0.67	positive regulation of biological process
GO:0048522	0.66	positive regulation of cellular process
GO:0009893	0.66	positive regulation of metabolic process
GO:0045935	0.65	positive regulation of nucleobase-containing compound metabolic process
GO:0031328	0.65	positive regulation of cellular biosynthetic process
GO:0010628	0.65	positive regulation of gene expression
GO:0010557	0.65	positive regulation of macromolecule biosynthetic process
GO:0045893	0.64	positive regulation of transcription, DNA-templated
GO:0006357	0.63	regulation of transcription from RNA polymerase II promoter
GO:0008152	0.62	metabolic process
GO:0071704	0.61	organic substance metabolic process
GO:0045944	0.60	positive regulation of transcription from RNA polymerase II promoter
GO:0044238	0.60	primary metabolic process
GO:0044237	0.60	cellular metabolic process
GO:0044260	0.58	cellular macromolecule metabolic process
GO:0006807	0.56	nitrogen compound metabolic process
GO:0006139	0.55	nucleobase-containing compound metabolic process
GO:1901576	0.54	organic substance biosynthetic process
GO:0044249	0.54	cellular biosynthetic process
GO:0016070	0.54	RNA metabolic process
GO:0044271	0.53	cellular nitrogen compound biosynthetic process
GO:0009059	0.53	macromolecule biosynthetic process
GO:0034645	0.52	cellular macromolecule biosynthetic process
GO:0032774	0.52	RNA biosynthetic process
GO:0006351	0.51	transcription, DNA-templated
GO:0044699	0.50	single-organism process

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044424	1.00	intracellular part
GO:0043231	0.90	intracellular membrane-bounded organelle
GO:0005634	0.88	nucleus
GO:0005737	0.53	cytoplasm

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	1qbaA	0.212	6.23	0.035	0.317	3.2.1.52	NA
2	0.060	2hr7A	0.181	6.90	0.049	0.286	2.7.10.1	256,270
3	0.060	1b0pA	0.175	6.79	0.013	0.269	1.2.7.1	NA
4	0.060	2vumA	0.188	7.25	0.043	0.305	2.7.7.6	NA
5	0.060	1ynnD	0.194	6.67	0.024	0.294	2.7.7.6	248,250,259,271

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
1	0.01	1mneA	0.191	7.31	0.041	0.311	0.34	POP	complex1.pdb.gz	260,261,262,263
2	0.01	2xzhA	0.103	7.46	0.053	0.172	0.19	VH2	complex2.pdb.gz	255,258,273
3	0.01	1c9iB	0.104	5.79	0.011	0.149	0.25	III	complex3.pdb.gz	250,251,258,274
4	0.01	3tw6C	0.188	7.26	0.076	0.305	0.19	ADP	complex4.pdb.gz	257,260,274,275,276
5	0.01	2xo8A	0.150	7.28	0.047	0.250	0.20	H70	complex5.pdb.gz	253,254,257,260
6	0.01	3bz9A	0.143	7.54	0.046	0.244	0.10	UUU	complex6.pdb.gz	253,254,255,256,257,263,264
7	0.01	1c9iA	0.115	6.36	0.041	0.174	0.19	III	complex7.pdb.gz	250,251,252,257,258,262
8	0.01	3tw6D	0.179	7.26	0.016	0.292	0.15	ADP	complex8.pdb.gz	256,257,269,276
9	0.01	3tw6A	0.198	6.94	0.039	0.311	0.21	ADP	complex9.pdb.gz	258,259,278
10	0.01	2xzgA	0.112	5.89	0.030	0.160	0.19	VH1	complex10.pdb.gz	258,260,273

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

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References:
1.	Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. In preparation, 2020.