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Template proteins with similar binding site:
Click to view | Rank | CscoreLB | PDB Hit | TM-score | RMSDa | IDENa | Cov. | BS-score | Lig. Name | Download Complex | Predicted binding site residues |
| 1 | 0.14 | 1kfaH | 0.730 | 1.54 | 0.181 | 0.817 | 0.49 | GA4 | complex1.pdb.gz | 48,50,69,70 |
| 2 | 0.12 | 2igfH | 0.740 | 1.48 | 0.200 | 0.826 | 0.92 | III | complex2.pdb.gz | 48,50,68,69,70,72,73,75,113 |
| 3 | 0.05 | 2vq1E | 0.730 | 1.33 | 0.253 | 0.791 | 0.64 | GLY | complex3.pdb.gz | 57,104,105 |
| 4 | 0.04 | 1e6o1 | 0.710 | 1.51 | 0.231 | 0.791 | 0.40 | III | complex4.pdb.gz | 52,54,56,61,62,64,67,68,110 |
| Click on the radio buttons to visualize predicted binding site and residues. |
(a) | CscoreLB is the confidence score of predicted binding site. CscoreLB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction. |
(b) | BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
| (c) | TM-score is a measure of global structural similarity between query and template protein. |
(d) | RMSDa the RMSD between residues that are structurally aligned by TM-align. |
(e) | IDENa is the percentage sequence identity in the structurally aligned region. |
(f) | Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein. |
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