| Swiss ID: nk1r_human |
| Protein Name: Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) |
| Organism: Homo sapiens (Human). |
| Seqeunce Length: 407 |
| MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS |
| Multiple Sequence Alignment |
| Experimental Restraints: |
| Contact Restraint: F264-I290 PMID of associated paper: 9261122 |
| Contact Restraint: I204-A115 PMID of associated paper: 9443945 |
| : MSA PMID of associated paper: 0 |
| Orientation Restraint: C152 PMID of associated paper: 1281470 |
| Orientation Restraint: I290 PMID of associated paper: 1281470 |
| Orientation Restraint: Q284 PMID of associated paper: 8384323 |
| Orientation Restraint: Y287 PMID of associated paper: 7510519 |
| Orientation Restraint: H265 PMID of associated paper: 7509807 |
| Orientation Restraint: F268 PMID of associated paper: 7532789 |
| Orientation Restraint: I204 PMID of associated paper: 9443945 |
| Orientation Restraint: A115 PMID of associated paper: 9443945 |
| Orientation Restraint: A294 PMID of associated paper: 9443945 |
| Orientation Restraint: G166 PMID of associated paper: 9373180 |
| Orientation Restraint: Y167 PMID of associated paper: 9373180 |
| Orientation Restraint: L203 PMID of associated paper: 9547942 |
| Experimental Data: |
| Experimental Data: C152F PMID of associated paper: 1281470 |
| Experimental Data: I290S PMID of associated paper: 1281470 |
| Experimental Data: H197Q PMID of associated paper: 8384323 |
| Experimental Data: H197F PMID of associated paper: 8384323 |
| Experimental Data: H197K PMID of associated paper: 8384323 |
| Experimental Data: H197S PMID of associated paper: 8384323 |
| Experimental Data: H197A PMID of associated paper: 8384323 |
| Experimental Data: H197Y PMID of associated paper: 8384323 |
| Experimental Data: T201A PMID of associated paper: 8384323 |
| Experimental Data: Q284A PMID of associated paper: 8384323 |
| Experimental Data: Y287Q PMID of associated paper: 7510519 |
| Experimental Data: Y287F PMID of associated paper: 7510519 |
| Experimental Data: Y287W PMID of associated paper: 7510519 |
| Experimental Data: Y287A PMID of associated paper: 7510519 |
| Experimental Data: Y287S PMID of associated paper: 7510519 |
| Experimental Data: Y287H PMID of associated paper: 7510519 |
| Experimental Data: H265Y PMID of associated paper: 7509807 |
| Experimental Data: H265A PMID of associated paper: 7509807 |
| Experimental Data: H265Q PMID of associated paper: 7509807 |
| Experimental Data: H265F PMID of associated paper: 7506676 |
| Experimental Data: H265S PMID of associated paper: 8300604 |
| Experimental Data: S169A PMID of associated paper: 8195129 |
| Experimental Data: F268H PMID of associated paper: 7532789 |
| Experimental Data: L269H PMID of associated paper: 7532789 |
| Experimental Data: T201H PMID of associated paper: 7532789 |
| Experimental Data: I198A PMID of associated paper: 9261122 |
| Experimental Data: V200A PMID of associated paper: 9261122 |
| Experimental Data: F268A PMID of associated paper: 9261122 |
| Experimental Data: I290A PMID of associated paper: 9261122 |
| Experimental Data: Y196 PMID of associated paper: 8702757 |
| Experimental Data: V195R PMID of associated paper: 10214937 |
| Experimental Data: I204H PMID of associated paper: 9443945 |
| Experimental Data: A115V PMID of associated paper: 9443945 |
| Experimental Data: T201I PMID of associated paper: 9443945 |
| Experimental Data: F268W PMID of associated paper: 9443945 |
| Experimental Data: A294V PMID of associated paper: 9443945 |
| Experimental Data: G166C PMID of associated paper: 9373180 |
| Experimental Data: Y167F PMID of associated paper: 9373180 |
| Experimental Data: I204A PMID of associated paper: 9547942 |
| Experimental Data: L203A PMID of associated paper: 9547942 |
| Experimental Data: C152V PMID of associated paper: 10651631 |
| Experimental Data: C199V PMID of associated paper: 10651631 |
| Experimental Data: C306S PMID of associated paper: 10651631 |
| Experimental Data: C307S PMID of associated paper: 10651631 |
| Experimental Data: C306A PMID of associated paper: 10651631 |
| Experimental Data: C307F PMID of associated paper: 10651631 |
| Experimental Data: H197V PMID of associated paper: 10651631 |
| Experimental Data: F264-I290 PMID of associated paper: 9261122 |
| Experimental Data: I204-A115 PMID of associated paper: 9443945 |
| Experimental Data: C152F PMID of associated paper: 1281470 |
| Experimental Data: I290S PMID of associated paper: 1281470 |
| Experimental Data: S80C PMID of associated paper: 1281470 |
| Experimental Data: V116L PMID of associated paper: 1281470 |
| Experimental Data: I266V PMID of associated paper: 1281470 |
| Experimental Data: H108Q PMID of associated paper: 1281469 |
| Experimental Data: M291F PMID of associated paper: 1281469 |
| Experimental Data: T40A PMID of associated paper: 8384323 |
| Experimental Data: Q284A PMID of associated paper: 8384323 |
| Experimental Data: E78A PMID of associated paper: 7510519 |
| Experimental Data: E78Q PMID of associated paper: 7510519 |
| Experimental Data: N85Q PMID of associated paper: 7510519 |
| Experimental Data: N85S PMID of associated paper: 7510519 |
| Experimental Data: N85A PMID of associated paper: 7510519 |
| Experimental Data: Y205A PMID of associated paper: 7510519 |
| Experimental Data: Y287Q PMID of associated paper: 7510519 |
| Experimental Data: Y287F PMID of associated paper: 7510519 |
| Experimental Data: Y287W PMID of associated paper: 7510519 |
| Experimental Data: Y287A PMID of associated paper: 7510519 |
| Experimental Data: Y287S PMID of associated paper: 7510519 |
| Experimental Data: Y287H PMID of associated paper: 7510519 |
| Experimental Data: H265Y PMID of associated paper: 7509807 |
| Experimental Data: H265A PMID of associated paper: 7509807 |
| Experimental Data: H265Q PMID of associated paper: 7509807 |
| Experimental Data: H265F PMID of associated paper: 7506676 |
| Experimental Data: H265S PMID of associated paper: 8300604 |
| Experimental Data: M81A PMID of associated paper: 8195129 |
| Experimental Data: N109A PMID of associated paper: 8195129 |
| Experimental Data: P112A PMID of associated paper: 8195129 |
| Experimental Data: P164A PMID of associated paper: 8195129 |
| Experimental Data: Q165A PMID of associated paper: 8195129 |
| Experimental Data: Q165S PMID of associated paper: 8195129 |
| Experimental Data: Q165N PMID of associated paper: 8195129 |
| Experimental Data: Y168A PMID of associated paper: 8195129 |
| Experimental Data: F268H PMID of associated paper: 7532789 |
| Experimental Data: P112H PMID of associated paper: 8947044 |
| Experimental Data: N109H PMID of associated paper: 8947044 |
| Experimental Data: H108A PMID of associated paper: 8947044 |
| Experimental Data: P112D PMID of associated paper: 9261122 |
| Experimental Data: F264A PMID of associated paper: 9261122 |
| Experimental Data: F264Y PMID of associated paper: 9261122 |
| Experimental Data: F267A PMID of associated paper: 9261122 |
| Experimental Data: F267Y PMID of associated paper: 9261122 |
| Experimental Data: F268A PMID of associated paper: 9261122 |
| Experimental Data: I290A PMID of associated paper: 9261122 |
| Experimental Data: Y216F PMID of associated paper: 8845375 |
| Experimental Data: Y216W PMID of associated paper: 8845375 |
| Experimental Data: Y216L PMID of associated paper: 8845375 |
| Experimental Data: Y216E PMID of associated paper: 8845375 |
| Experimental Data: Y216A PMID of associated paper: 8845375 |
| Experimental Data: I204H PMID of associated paper: 9443945 |
| Experimental Data: A115V PMID of associated paper: 9443945 |
| Experimental Data: F268W PMID of associated paper: 9443945 |
| Experimental Data: A294V PMID of associated paper: 9443945 |
| Experimental Data: G166C PMID of associated paper: 9373180 |
| Experimental Data: Y167F PMID of associated paper: 9373180 |
| Experimental Data: I204A PMID of associated paper: 9547942 |
| Experimental Data: L203A PMID of associated paper: 9547942 |
| Experimental Data: W155A PMID of associated paper: 9547942 |
| Experimental Data: W155F PMID of associated paper: 9547942 |
| Experimental Data: C152V PMID of associated paper: 10651631 |
| Experimental Data: C255V PMID of associated paper: 10651631 |
| Experimental Data: C260S PMID of associated paper: 10651631 |
| Experimental Data: C255S PMID of associated paper: 10651631 |
| Experimental Data: C260C PMID of associated paper: 10651631 |
| Experimental Data: M291C PMID of associated paper: 10908293 |
| Experimental Data: A162L PMID of associated paper: 9389383 |
| Experimental Data: MSA PMID of associated paper: 0 |
| GPCR Related Corss-reference Links: |
| GPCRDB GPCR-OKB UniProt_P25103 |