| Swiss ID: mc4r_human |
| Protein Name: Melanocortin 4 (MC4-R) |
| Organism: Human |
| Seqeunce Length: 332 |
| MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL IYALRSQELRKTFKEIICCYPLGGLCDLSSRY |
| Multiple Sequence Alignment |
| Experimental Restraints: |
| Contact Restraint: E61-D90 PMID of associated paper: 11101306 |
| Contact Restraint: V50-I102 PMID of associated paper: 12499395 |
| Contact Restraint: I125-F184 PMID of associated paper: 12604699 |
| Contact Restraint: D126-C196 PMID of associated paper: 11101306 |
| : MSA PMID of associated paper: 0 |
| Orientation Restraint: F51 PMID of associated paper: 12646666 |
| Orientation Restraint: S58 PMID of associated paper: 12499395 |
| Orientation Restraint: N62 PMID of associated paper: 12499395 |
| Orientation Restraint: E100 PMID of associated paper: 11101306 |
| Orientation Restraint: I103 PMID of associated paper: 12499395 |
| Orientation Restraint: D126 PMID of associated paper: 11101306 |
| Orientation Restraint: S127 PMID of associated paper: 12499395 |
| Orientation Restraint: C130 PMID of associated paper: 11101306 |
| Orientation Restraint: C196 PMID of associated paper: 11101306 |
| Orientation Restraint: T199 PMID of associated paper: 11101306 |
| Orientation Restraint: F202 PMID of associated paper: 16030156 |
| Orientation Restraint: M204 PMID of associated paper: 11101306 |
| Orientation Restraint: L250 PMID of associated paper: 10903341 |
| Orientation Restraint: I251 PMID of associated paper: 10508193 |
| Orientation Restraint: W258 PMID of associated paper: 11101306 |
| Orientation Restraint: F261 PMID of associated paper: 11101306 |
| Orientation Restraint: F262 PMID of associated paper: 16114870 |
| Orientation Restraint: F284 PMID of associated paper: 12604699 |
| Orientation Restraint: N285 PMID of associated paper: 11101306 |
| Orientation Restraint: S295 PMID of associated paper: 16030156 |
| Orientation Restraint: D298 PMID of associated paper: 11101306 |
| Orientation Restraint: P299 PMID of associated paper: 12499395 |
| Orientation Restraint: I301 PMID of associated paper: 10903341 |
| Experimental Data: |
| Experimental Data: H6A PMID of associated paper: 11101306 |
| Experimental Data: H6R PMID of associated paper: 16114870 |
| Experimental Data: T11A PMID of associated paper: 12646666 |
| Experimental Data: T11S PMID of associated paper: 10903341 |
| Experimental Data: R18C PMID of associated paper: 10903341 |
| Experimental Data: S30F PMID of associated paper: 10508193 |
| Experimental Data: S30P PMID of associated paper: 12499395 |
| Experimental Data: Y35X PMID of associated paper: 15951321 |
| Experimental Data: D37V PMID of associated paper: 10508193 |
| Experimental Data: P48S PMID of associated paper: 12959994 |
| Experimental Data: E49A PMID of associated paper: 11101306 |
| Experimental Data: F51L PMID of associated paper: 12646666 |
| Experimental Data: S58C PMID of associated paper: 12499395 |
| Experimental Data: N62S PMID of associated paper: 12499395 |
| Experimental Data: P78L PMID of associated paper: 10508193 |
| Experimental Data: E100A PMID of associated paper: 11101306 |
| Experimental Data: I103V PMID of associated paper: 12499395 |
| Experimental Data: V103I PMID of associated paper: 16030156 |
| Experimental Data: T112M PMID of associated paper: 10508193 |
| Experimental Data: D122A PMID of associated paper: 11101306 |
| Experimental Data: D122N PMID of associated paper: 11101306 |
| Experimental Data: D126A PMID of associated paper: 11101306 |
| Experimental Data: D126L PMID of associated paper: 11101306 |
| Experimental Data: D126N PMID of associated paper: 11101306 |
| Experimental Data: D126S PMID of associated paper: 11101306 |
| Experimental Data: S127L PMID of associated paper: 12499395 |
| Experimental Data: C130A PMID of associated paper: 11101306 |
| Experimental Data: T150I PMID of associated paper: 10903341 |
| Experimental Data: A154D PMID of associated paper: 16030156 |
| Experimental Data: Y157S PMID of associated paper: 12959994 |
| Experimental Data: K164A PMID of associated paper: 11101306 |
| Experimental Data: R165A PMID of associated paper: 11101306 |
| Experimental Data: R165Q PMID of associated paper: 12499395 |
| Experimental Data: R165W PMID of associated paper: 10508193 |
| Experimental Data: S190A PMID of associated paper: 12604699 |
| Experimental Data: S191A PMID of associated paper: 12604699 |
| Experimental Data: C196A PMID of associated paper: 11101306 |
| Experimental Data: T199A PMID of associated paper: 11101306 |
| Experimental Data: F202L PMID of associated paper: 16030156 |
| Experimental Data: M204A PMID of associated paper: 11101306 |
| Experimental Data: N240S PMID of associated paper: 16030156 |
| Experimental Data: A244E PMID of associated paper: 12499395 |
| Experimental Data: L250Q PMID of associated paper: 10903341 |
| Experimental Data: I251L PMID of associated paper: 10508193 |
| Experimental Data: W258A PMID of associated paper: 11101306 |
| Experimental Data: F261A PMID of associated paper: 11101306 |
| Experimental Data: F262A PMID of associated paper: 16114870 |
| Experimental Data: Y268A PMID of associated paper: 11101306 |
| Experimental Data: C271A PMID of associated paper: 15115780 |
| Experimental Data: C271T PMID of associated paper: 12690102 |
| Experimental Data: C271Y PMID of associated paper: 12499395 |
| Experimental Data: N274S PMID of associated paper: 12959994 |
| Experimental Data: F284A PMID of associated paper: 12604699 |
| Experimental Data: N285A PMID of associated paper: 11101306 |
| Experimental Data: S295P PMID of associated paper: 16030156 |
| Experimental Data: D298A PMID of associated paper: 11101306 |
| Experimental Data: P299H PMID of associated paper: 12499395 |
| Experimental Data: I301T PMID of associated paper: 10903341 |
| Experimental Data: R305A PMID of associated paper: 11101306 |
| Experimental Data: S306A PMID of associated paper: 12639913 |
| Experimental Data: R310A PMID of associated paper: 15865442 |
| Experimental Data: K311A PMID of associated paper: 15865442 |
| Experimental Data: T312A PMID of associated paper: 12639913 |
| Experimental Data: F313A PMID of associated paper: 15865442 |
| Experimental Data: K314A PMID of associated paper: 15865442 |
| Experimental Data: E315A PMID of associated paper: 15865442 |
| Experimental Data: I316A PMID of associated paper: 15865442 |
| Experimental Data: I316T PMID of associated paper: 12594226 |
| Experimental Data: I317A PMID of associated paper: 15865442 |
| Experimental Data: I317T PMID of associated paper: 10508193 |
| Experimental Data: S329A PMID of associated paper: 12639913 |
| Experimental Data: S330A PMID of associated paper: 12639913 |
| Experimental Data: Y268I PMID of associated paper: 10358030 |
| Experimental Data: C271 PMID of associated paper: 10318826 |
| Experimental Data: S270T PMID of associated paper: 10358030 |
| Experimental Data: M281T PMID of associated paper: 10358030 |
| Experimental Data: E61-D90 PMID of associated paper: 11101306 |
| Experimental Data: V50-I102 PMID of associated paper: 12499395 |
| Experimental Data: I125-F184 PMID of associated paper: 12604699 |
| Experimental Data: D126-C196 PMID of associated paper: 11101306 |
| Experimental Data: V50M PMID of associated paper: 12499395 |
| Experimental Data: F51L PMID of associated paper: 12646666 |
| Experimental Data: S58C PMID of associated paper: 12499395 |
| Experimental Data: E61A PMID of associated paper: 11101306 |
| Experimental Data: N62S PMID of associated paper: 12499395 |
| Experimental Data: D90A PMID of associated paper: 11101306 |
| Experimental Data: G98R PMID of associated paper: 12959994 |
| Experimental Data: E100A PMID of associated paper: 11101306 |
| Experimental Data: I102S PMID of associated paper: 12499395 |
| Experimental Data: I102T PMID of associated paper: 16030156 |
| Experimental Data: I103V PMID of associated paper: 12499395 |
| Experimental Data: V103I PMID of associated paper: 16030156 |
| Experimental Data: I125F PMID of associated paper: 12604699 |
| Experimental Data: D126A PMID of associated paper: 11101306 |
| Experimental Data: D126L PMID of associated paper: 11101306 |
| Experimental Data: D126N PMID of associated paper: 11101306 |
| Experimental Data: D126S PMID of associated paper: 11101306 |
| Experimental Data: S127L PMID of associated paper: 12499395 |
| Experimental Data: I129A PMID of associated paper: 16114870 |
| Experimental Data: C130A PMID of associated paper: 11101306 |
| Experimental Data: I137T PMID of associated paper: 10903341 |
| Experimental Data: I170V PMID of associated paper: 10903341 |
| Experimental Data: F184L PMID of associated paper: 12604699 |
| Experimental Data: F184M PMID of associated paper: 12604699 |
| Experimental Data: F184S PMID of associated paper: 12604699 |
| Experimental Data: C196A PMID of associated paper: 11101306 |
| Experimental Data: T199A PMID of associated paper: 11101306 |
| Experimental Data: M200A PMID of associated paper: 11101306 |
| Experimental Data: M200V PMID of associated paper: 12646666 |
| Experimental Data: F202L PMID of associated paper: 16030156 |
| Experimental Data: T203A PMID of associated paper: 11101306 |
| Experimental Data: M204A PMID of associated paper: 11101306 |
| Experimental Data: H214A PMID of associated paper: 11101306 |
| Experimental Data: L250Q PMID of associated paper: 10903341 |
| Experimental Data: I251L PMID of associated paper: 10508193 |
| Experimental Data: G252S PMID of associated paper: 10508193 |
| Experimental Data: V253I PMID of associated paper: 12499395 |
| Experimental Data: W258A PMID of associated paper: 11101306 |
| Experimental Data: F261A PMID of associated paper: 11101306 |
| Experimental Data: F262A PMID of associated paper: 16114870 |
| Experimental Data: H264A PMID of associated paper: 11101306 |
| Experimental Data: F267A PMID of associated paper: 11101306 |
| Experimental Data: F267L PMID of associated paper: 12604699 |
| Experimental Data: H283A PMID of associated paper: 11101306 |
| Experimental Data: F284A PMID of associated paper: 12604699 |
| Experimental Data: N285A PMID of associated paper: 11101306 |
| Experimental Data: S295P PMID of associated paper: 16030156 |
| Experimental Data: D298A PMID of associated paper: 11101306 |
| Experimental Data: P299H PMID of associated paper: 12499395 |
| Experimental Data: I301T PMID of associated paper: 10903341 |
| Experimental Data: V67 PMID of associated paper: 10358030 |
| Experimental Data: F267 PMID of associated paper: 10358030 |
| Experimental Data: F202 PMID of associated paper: 10358030 |
| Experimental Data: MSA PMID of associated paper: 0 |
| GPCR Related Corss-reference Links: |
| GPCRDB GPCR-OKB UniProt_P32245 |