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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Orexin receptor antagonist 6
Molecular formula	C21H19FN6O2
IUPAC name	2-[(3R,6R)-1-[3-fluoro-2-(triazol-2-yl)benzoyl]-6-methylpiperidin-3-yl]oxypyridine-4-carbonitrile
Molecular weight	406.421
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.1
Synonyms	CHEMBL3642120 US20130102619, 6 BDBM97375 SCHEMBL14876722
Inchi Key	GCPJITKYQCWZPV-GDBMZVCRSA-N
Inchi ID	InChI=1S/C21H19FN6O2/c1-14-5-6-16(30-19-11-15(12-23)7-8-24-19)13-27(14)21(29)17-3-2-4-18(22)20(17)28-25-9-10-26-28/h2-4,7-11,14,16H,5-6,13H2,1H3/t14-,16-/m1/s1
PubChem CID	71526211
ChEMBL	CHEMBL3642120
IUPHAR	N/A
BindingDB	97375
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
93147	Orexin receptor type 1	O43613	HCRTR1	Homo sapiens (Human)	425
93149	Orexin receptor type 1	P56718	Hcrtr1	Rattus norvegicus (Rat)	416
93146	Orexin receptor type 2	P56719	Hcrtr2	Rattus norvegicus (Rat)	460
93148	Orexin receptor type 2	O43614	HCRTR2	Homo sapiens (Human)	444

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