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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Orexin receptor antagonist 34
Molecular formula	C23H20FN5O2
IUPAC name	2-[(3R,6R)-1-(4-fluoro-2-pyrimidin-2-ylbenzoyl)-6-methylpiperidin-3-yl]oxypyridine-4-carbonitrile
Molecular weight	417.444
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.1
Synonyms	SCHEMBL14877185 CHEMBL3642147 US20130102619, 34 BDBM97402
Inchi Key	DVQKBFBIBGIHAF-CRAIPNDOSA-N
Inchi ID	InChI=1S/C23H20FN5O2/c1-15-3-5-18(31-21-11-16(13-25)7-10-26-21)14-29(15)23(30)19-6-4-17(24)12-20(19)22-27-8-2-9-28-22/h2,4,6-12,15,18H,3,5,14H2,1H3/t15-,18-/m1/s1
PubChem CID	71526648
ChEMBL	CHEMBL3642147
IUPHAR	N/A
BindingDB	97402
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
70135	Orexin receptor type 1	O43613	HCRTR1	Homo sapiens (Human)	425
70136	Orexin receptor type 1	P56718	Hcrtr1	Rattus norvegicus (Rat)	416
70133	Orexin receptor type 2	P56719	Hcrtr2	Rattus norvegicus (Rat)	460
70134	Orexin receptor type 2	O43614	HCRTR2	Homo sapiens (Human)	444

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