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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL372721
Molecular formula	C26H28Cl2N4O
IUPAC name	1-[(1S,2R,5S)-5-(4-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-3-(3,5-dichlorophenyl)-1-(2-pyrrolidin-1-ylethyl)urea
Molecular weight	483.437
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.3
Synonyms	1-[(1S,2R,5S)-5-(4-Cyano-phenyl)-bicyclo[3.1.0]hex-2-yl]-3-(3,5-dichloro-phenyl)-1-(2-pyrrolidin-1-yl-ethyl)-urea BDBM50164245
Inchi Key	BJNIDUIQWUGXOW-DGWZTRNLSA-N
Inchi ID	InChI=1S/C26H28Cl2N4O/c27-20-13-21(28)15-22(14-20)30-25(33)32(12-11-31-9-1-2-10-31)24-7-8-26(16-23(24)26)19-5-3-18(17-29)4-6-19/h3-6,13-15,23-24H,1-2,7-12,16H2,(H,30,33)/t23-,24-,26-/m1/s1
PubChem CID	10195667
ChEMBL	CHEMBL372721
IUPHAR	N/A
BindingDB	50164245
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
25300	Melanin-concentrating hormone receptor 1	Q8JZL2	Mchr1	Mus musculus (Mouse)	353
25301	Melanin-concentrating hormone receptor 1	Q99705	MCHR1	Homo sapiens (Human)	422
25299	Melanin-concentrating hormone receptor 2	Q969V1	MCHR2	Homo sapiens (Human)	340

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