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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	DORA-22
Molecular formula	C23H22F2N4O2
IUPAC name	[(2R,5R)-5-[(5-fluoropyridin-2-yl)oxymethyl]-2-methylpiperidin-1-yl]-(5-fluoro-2-pyrimidin-2-ylphenyl)methanone
Molecular weight	424.452
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.6
Synonyms	1088991-95-0 Methanone, ((2R,5R)-5-(((5-fluoro-2-pyridinyl)oxy)methyl)-2-methyl-1-piperidinyl)(5-fluoro-2-(2-pyrimidinyl)phenyl)- CHEMBL3655675 DORA22 BDBM104702 SCHEMBL1716753 DORA 22 DTXSID10148765 US8569311, 1-19 [ Show all ]
Inchi Key	ADNQCBKNFSDDHY-HZPDHXFCSA-N
Inchi ID	InChI=1S/C23H22F2N4O2/c1-15-3-4-16(14-31-21-8-6-18(25)12-28-21)13-29(15)23(30)20-11-17(24)5-7-19(20)22-26-9-2-10-27-22/h2,5-12,15-16H,3-4,13-14H2,1H3/t15-,16-/m1/s1
PubChem CID	25126515
ChEMBL	CHEMBL3655675
IUPHAR	N/A
BindingDB	104702
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
2899	Orexin receptor type 1	P56718	Hcrtr1	Rattus norvegicus (Rat)	416
2898	Orexin receptor type 2	P56719	Hcrtr2	Rattus norvegicus (Rat)	460

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