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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	SMR000354270
Molecular formula	C30H34N4O2
IUPAC name	1-N,3-N-dicyclohexyl-1-N,3-N-dipyridin-2-ylbenzene-1,3-dicarboxamide
Molecular weight	482.628
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	6.1
Synonyms	380459-13-2 MLS003915368 Oprea1_232767 MCULE-1062669494 ZINC9186026 AC1NNLY6 MolPort-004-002-302 CHEMBL1533238 1-N,3-N-dicyclohexyl-1-N,3-N-dipyridin-2-ylbenzene-1,3-dicarboxamide MLS001017976 AKOS034458836 N1,N3-dicyclohexyl-N1,N3-bis(pyridin-2-yl)benzene-1,3-dicarboxamide HMS2654C05 Z56830717 [ Show all ]
Inchi Key	GFMOZPMHGVTGCW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H34N4O2/c35-29(33(25-14-3-1-4-15-25)27-18-7-9-20-31-27)23-12-11-13-24(22-23)30(36)34(26-16-5-2-6-17-26)28-19-8-10-21-32-28/h7-13,18-22,25-26H,1-6,14-17H2
PubChem CID	5047011
ChEMBL	CHEMBL1533238
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Potency	10000.0 nM	PubChem BioAssay data set	ChEMBL

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