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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Uracil nucleotide/cysteinyl leukotriene receptor
Species	Homo sapiens (Human)
Gene	GPR17
Synonym	GPR17 P2Y-like receptor G-protein coupled receptor 17 R12 UDP/CysLT receptor uracil nucleotide/cysteinyl leukotriene receptor [ Show all ]
Disease	N/A
Length	367
Amino acid sequence	MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENMLFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCYLLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQRILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESSLSAKSEL
UniProt	Q13304
Protein Data Bank	N/A
GPCR-HGmod model	Q13304
3D structure model	This predicted structure model is from GPCR-EXP Q13304.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075162
IUPHAR	88
DrugBank	N/A

Ligand

Name	Uridine-5'-diphosphate sodium salt(1:3)
Molecular formula	C9H11N2Na3O12P2
IUPAC name	trisodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphate
Molecular weight	470.106
Hydrogen bond acceptor	12
Hydrogen bond donor	3
XlogP	None
Synonyms	trisodium 5'-o-[(phosphonatooxy)phosphinato]uridine Uridine-5'-diphosphate sodium AC1Q1UO1 Uridine 5'-(Trihydrogen Diphosphate) Sodium Salt 19817-91-5 MolPort-044-557-507 Uridine 5'-Diphosphate Sodium Salt A14009 AK175686 trisodium [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] phosphate CHEMBL1096401 Uridine 5'-(trihydrogendiphosphate), trisodium salt (9CI) 21931-53-3 sodium ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl diphosphate uridine diphosphate trisodium salt AC1L3FCW AKOS027250770 Uridine 5 inverted exclamation mark -Diphosphate Sodium Salt EINECS 243-345-4 Uridine 5'-(trisodium pyrophosphate) 617D5B10-CC3A-441B-8F3B-5A18B398CA1A [ Show all ]
Inchi Key	GFASEGWJDXDCKZ-LLWADOMFSA-K
Inchi ID	InChI=1S/C9H14N2O12P2.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1
PubChem CID	88264
ChEMBL	CHEMBL1096401
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1140.0 nM	PMID20394377	ChEMBL

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