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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Mus musculus (Mouse)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 Serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProt	P35363
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5377
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	2-methoxy-N-[2-(4-phenylpiperazin-1-yl)ethyl]benzamide
Molecular formula	C20H25N3O2
IUPAC name	2-methoxy-N-[2-(4-phenylpiperazin-1-yl)ethyl]benzamide
Molecular weight	339.439
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	2.6
Synonyms	BDBM114629 SR-01000216910-3 F5264-0059 2-methoxy-N-[2-(4-phenyl-1-piperazinyl)ethyl]benzamide Oprea1_699641 AC1LF5IA CHEMBL1622074 ZINC55111898 MCULE-7250395909 AKOS024728174 SR-01000216910 cid_747202 2-methoxy-N-(2-(4-phenylpiperazin-1-yl)ethyl)benzamide Oprea1_339845 2-methoxy-N-[2-(4-phenylpiperazino)ethyl]benzamide [ Show all ]
Inchi Key	GCTHHCZLCQZWOP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H25N3O2/c1-25-19-10-6-5-9-18(19)20(24)21-11-12-22-13-15-23(16-14-22)17-7-3-2-4-8-17/h2-10H,11-16H2,1H3,(H,21,24)
PubChem CID	747202
ChEMBL	N/A
IUPHAR	N/A
BindingDB	114629
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	76083.0 nM	N/A	BindingDB

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