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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Adenosine receptor A2b
Species	Homo sapiens (Human)
Gene	ADORA2B
Synonym	adenosine receptor A2b A2BR A2B receptor A2b
Disease	Paroxysmal supraventricular tachycardia Non-insulin dependent diabetes Hypertension Herpes simplex virus infection Apnea Asthma [ Show all ]
Length	332
Amino acid sequence	MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
UniProt	P29275
Protein Data Bank	N/A
GPCR-HGmod model	P29275
3D structure model	This predicted structure model is from GPCR-EXP P29275.
BioLiP	N/A
Therapeutic Target Database	T86679
ChEMBL	CHEMBL255
IUPHAR	20
DrugBank	BE0000241

Ligand

Name	N-(2-hydroxyethyl)-8-methoxy-2-oxo-2H-chromene-3-carboxamide
Molecular formula	C13H13NO5
IUPAC name	N-(2-hydroxyethyl)-8-methoxy-2-oxochromene-3-carboxamide
Molecular weight	263.249
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	1.2
Synonyms	AKOS024602972 Oprea1_266237 F1107-0287 SR-01000247955-1 683249-46-9 Oprea1_521720 MCULE-8956316244 ZINC2999339 AC1M55IU N-(2-hydroxyethyl)-8-methoxy-2-oxochromene-3-carboxamide CHEMBL2042083 SR-01000247955 MolPort-002-088-919 [ Show all ]
Inchi Key	AMVJXRCZLMEIAU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H13NO5/c1-18-10-4-2-3-8-7-9(12(16)14-5-6-15)13(17)19-11(8)10/h2-4,7,15H,5-6H2,1H3,(H,14,16)
PubChem CID	2295666
ChEMBL	CHEMBL2042083
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	7.0 %	PMID22677030	ChEMBL

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