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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 1
Species	Homo sapiens (Human)
Gene	NPY1R
Synonym	neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor Y1-R [ Show all ]
Disease	Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder Cardiovascular disorder Hypertension [ Show all ]
Length	384
Amino acid sequence	MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
UniProt	P25929
Protein Data Bank	5zbh
GPCR-HGmod model	P25929
3D structure model	This structure is from PDB ID 5zbh.
BioLiP	BL0411971
Therapeutic Target Database	T89213
ChEMBL	CHEMBL4777
IUPHAR	305
DrugBank	N/A

Ligand

Name	2-[4-(2-methoxyphenoxy)-3-nitrophenyl]quinoxaline
Molecular formula	C21H15N3O4
IUPAC name	2-[4-(2-methoxyphenoxy)-3-nitrophenyl]quinoxaline
Molecular weight	373.368
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	4.2
Synonyms	Oprea1_050663 HMS2658L16 SR-01000439244-1 AKOS001619949 MolPort-000-745-832 ZINC1109954 1-(2-methoxyphenoxy)-2-nitro-4-quinoxalin-2-ylbenzene CHEMBL1534392 SMR000293571 MCULE-6316908924 ST45066757 BDBM61785 Oprea1_024618 2-[4-(2-methoxyphenoxy)-3-nitro-phenyl]quinoxaline cid_1288612 SR-01000439244 AC1LPJTE MLS000672134 STK388831 [ Show all ]
Inchi Key	AMUIZQDUZFTYFV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H15N3O4/c1-27-20-8-4-5-9-21(20)28-19-11-10-14(12-18(19)24(25)26)17-13-22-15-6-2-3-7-16(15)23-17/h2-13H,1H3
PubChem CID	1288612
ChEMBL	CHEMBL1534392
IUPHAR	N/A
BindingDB	61785
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<35430.0 nM	PubChem BioAssay data set	ChEMBL
EC50	35430.0 nM	N/A	BindingDB

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