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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	PAPP
Molecular formula	C19H22F3N3
IUPAC name	4-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]aniline
Molecular weight	349.401
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.0
Synonyms	NCGC00015907-04 p-Aminophenethyl-m-trifluoromethylphenyl piperazine SR-01000075576-1 4-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)aniline Biomol-NT_000160 CTK8D5097 J-011585 LY-165,163, solid MFCD00055098 NCGC00094399-02 PAPP (LY-165,163) SELECTIVE 5-HT1A SERO ZINC1619831 8HAJ699EWG C19H22F3N3 EU-0101132 LP01132 NCGC00015907-02 NCI60_009079 SMR000326833 AKOS030547154 HMS3263D05 LY 165163 NCGC00015907-05 p-NH2-PE-Tfmpp Tox21_501132 4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine BPBio1_000375 D0T4PS Lopac-S-009 LY-165,163; p-Aminophenethyl-m-trifluoromethylphenyl piperazine MLS000859974 NCGC00094399-03 S-009 AC1L3TO7 CCG-205206 GTPL18 LS-173712 NCGC00015907-03 NSC628235 SR-01000075576 1814-64-8 Benzenamine, 4-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)- CHEMBL1256693 HMS3369D03 LY-165,163 NCGC00094399-01 UNII-8HAJ699EWG 4-[2-[4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]aniline BRD-K14282469-001-01-5 DTXSID30171136 Lopac0_001132 LY-165163 NCGC00015907-01 NCGC00261817-01 SCHEMBL3976547 1-(2-(4-Aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine AC1Q4K3D CHEBI:92250 HMS2232I03 LY 165,163 [ Show all ]
Inchi Key	GAAKALASJNGQKD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2
PubChem CID	121930
ChEMBL	CHEMBL1256693
IUPHAR	18
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	1000.0 nM	PubChem BioAssay data set	ChEMBL

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