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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Rattus norvegicus (Rat)
Gene	Htr4
Synonym	5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	406
Amino acid sequence	MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProt	Q62758
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4317
IUPHAR	9
DrugBank	N/A

Ligand

Name	CHEMBL34224
Molecular formula	C14H19ClN2O3
IUPAC name	(1-methylpiperidin-4-yl) 4-amino-5-chloro-2-methoxybenzoate
Molecular weight	298.767
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.3
Synonyms	AKOS010536375 4-Amino-5-chloro-2-methoxy-benzoic acid 1-methyl-piperidin-4-yl ester BDBM50282689
Inchi Key	FXYDPARKRWHKDN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H19ClN2O3/c1-17-5-3-9(4-6-17)20-14(18)10-7-11(15)12(16)8-13(10)19-2/h7-9H,3-6,16H2,1-2H3
PubChem CID	44281492
ChEMBL	CHEMBL34224
IUPHAR	N/A
BindingDB	50282689
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	23.0 nM	, Bioorg. Med. Chem. Lett., (1994) 4:12:1433	BindingDB,ChEMBL

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