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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Homo sapiens (Human)
Gene	HTR7
Synonym	5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 GPRFO 5-HT7 receptor 5-HTx 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [ Show all ]
Disease	Sleep disorders Schizophrenia Major depressive disorder
Length	479
Amino acid sequence	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProt	P34969
Protein Data Bank	N/A
GPCR-HGmod model	P34969
3D structure model	This predicted structure model is from GPCR-EXP P34969.
BioLiP	N/A
Therapeutic Target Database	T79062
ChEMBL	CHEMBL3155
IUPHAR	12
DrugBank	BE0000650, BE0004862

Ligand

Name	baicalein
Molecular formula	C15H10O5
IUPAC name	5,6,7-trihydroxy-2-phenylchromen-4-one
Molecular weight	270.24
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	1.7
Synonyms	ST057152 DTXSID2022389 ZINC3871633 HMS3655P18 KBio3_002435 MLS006011756 3WL NCGC00017236-06 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one NCGC00178204-01 AB0018364 Q-100550 Baicalein, 14 Sho-saiko-to BBL027840 Spectrum4_000537 C10023 TNP00121 GTPL5144 KB-47494 LMPK12111095 NCGC00017236-01 49QAH60606 NCGC00017236-10 5,6,7-trihydroxy-2-phenylchromen-4-one NSC-661431 AK168078 SBB067246 Baicalein, analytical reference material SPBio_000572 Biacalein SR-01000597499 D00YEV W-202870 HMS3268C22 KBio2_003475 MFCD00017459 NCGC00017236-04 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one NCGC00025282-03 5,7-Trihydroxyflavone NSC729192 AN-8474 SCHEMBL139617 Baicelein Spectrum2_000466 BRD-K72327355-001-06-3 SR-01000597499-4 STL146746 FT-0622548 HY-N0196 KBioGR_001173 MolPort-001-741-408 491-67-8 NCGC00017236-07 5,6,7-Trihydroxy-2-phenyl-chroman-4-one Noroxylin AC-7991 S00113 Baicalein, 8 SMP1_000037 BCP14393 Spectrum5_001418 CCG-38705 CHEMBL8260 Tocris-1761 HMS1922O22 KBio1_001798 LS-39842 NCGC00017236-02 4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-phenyl- NCGC00025282-01 5,6,7-Trihydroxyflavone NSC-729192 AKOS005747014 SC-04798 Baicalein, disposable screening library format SpecPlus_000758 BIDD:ER0121 SR-01000597499-1 SR-01000597499-6 DivK1c_006854 W-2736 HMS3649O19 KBio2_006043 MLS002473007 27462-75-5 NCGC00017236-05 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one NCGC00025282-04 Oprea1_765614 SDCCGMLS-0066744.P001 BaiKalein Spectrum3_001608 BSPBio_003215 SW219229-1 FXNFHKRTJBSTCS-UHFFFAOYSA-N IN1408 KBioSS_000907 N1858 491B678 NCGC00017236-08 5,6,7-trihydroxy-2-phenyl-chromen-4-one NSC 661431 AC1NQYPP s2268 Baicalein, 98% SMR000112462 BDBM50009001 Spectrum_000427 CHEBI:2979 CS-6159 UNII-49QAH60606 HMS2267F15 KBio2_000907 MCULE-8669340472 NCGC00017236-03 4H-1-Benzopyran-4-one,5,6,7-trihydroxy-2-phenyl- NCGC00025282-02 5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one NSC661431 ALBB-028286 SC-20654 Baicalein,(S) SPECTRUM1504002 BRD-K72327355-001-02-2 SR-01000597499-3 [ Show all ]
Inchi Key	FXNFHKRTJBSTCS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
PubChem CID	5281605
ChEMBL	CHEMBL8260
IUPHAR	N/A
BindingDB	50009001
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<350000.0 nM	PMID12713409	BindingDB,ChEMBL

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