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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	CHEMBL1385271
Molecular formula	C19H15ClN2O4
IUPAC name	N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]furan-2-carboxamide
Molecular weight	370.789
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.6
Synonyms	ZINC813647 N-(4-(2-chlorobenzamido)-3-methoxyphenyl)furan-2-carboxamide AC1LLYN0 HMS3309B21 N-{4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl}-2-furamide BDBM50336626 MLS002541992 ST50285862 Furan-2-carboxylic acid [4-(2-chloro-benzoylamino)-3-methoxy-phenyl]-amide N-(4-{[(2-chlorophenyl)carbonyl]amino}-3-methoxyphenyl)furan-2-carboxamide AKOS000609572 MCULE-9683550341 N-{4-[(2-chlorophenyl)carbonylamino]-3-methoxyphenyl}-2-furylcarboxamide MolPort-002-013-791 STK134930 HMS2154P09 N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]furan-2-carboxamide BAS 08837814 MLS000096735 SMR000074022 [ Show all ]
Inchi Key	FXIXZADJVWSXHM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H15ClN2O4/c1-25-17-11-12(21-19(24)16-7-4-10-26-16)8-9-15(17)22-18(23)13-5-2-3-6-14(13)20/h2-11H,1H3,(H,21,24)(H,22,23)
PubChem CID	1092661
ChEMBL	CHEMBL1385271
IUPHAR	N/A
BindingDB	50336626
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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