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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Metabotropic glutamate receptor 4
Species	Rattus norvegicus (Rat)
Gene	Grm4
Synonym	glutamate receptor GPRC1D mGlu4 receptor mGluR4
Disease	N/A for non-human GPCRs
Length	912
Amino acid sequence	MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI
UniProt	P31423
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2787
IUPHAR	292
DrugBank	N/A

Ligand

Name	CHEMBL1385271
Molecular formula	C19H15ClN2O4
IUPAC name	N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]furan-2-carboxamide
Molecular weight	370.789
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.6
Synonyms	MLS002541992 ST50285862 BDBM50336626 Furan-2-carboxylic acid [4-(2-chloro-benzoylamino)-3-methoxy-phenyl]-amide N-(4-{[(2-chlorophenyl)carbonyl]amino}-3-methoxyphenyl)furan-2-carboxamide MCULE-9683550341 N-{4-[(2-chlorophenyl)carbonylamino]-3-methoxyphenyl}-2-furylcarboxamide AKOS000609572 MolPort-002-013-791 STK134930 HMS2154P09 N-[4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl]furan-2-carboxamide MLS000096735 SMR000074022 BAS 08837814 N-(4-(2-chlorobenzamido)-3-methoxyphenyl)furan-2-carboxamide ZINC813647 HMS3309B21 N-{4-[(2-chlorobenzoyl)amino]-3-methoxyphenyl}-2-furamide AC1LLYN0 [ Show all ]
Inchi Key	FXIXZADJVWSXHM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H15ClN2O4/c1-25-17-11-12(21-19(24)16-7-4-10-26-16)8-9-15(17)22-18(23)13-5-2-3-6-14(13)20/h2-11H,1H3,(H,21,24)(H,22,23)
PubChem CID	1092661
ChEMBL	CHEMBL1385271
IUPHAR	N/A
BindingDB	50336626
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	122.3 %	PMID21247167	ChEMBL
EC50	1010.0 nM	PMID21247167	BindingDB,ChEMBL

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