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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	27692-91-7
Molecular formula	C12H20N2
IUPAC name	N'-ethyl-N,N-dimethyl-N'-phenylethane-1,2-diamine
Molecular weight	192.306
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	2.8
Synonyms	AJ-32529 DTXSID6067335 N,N-Dimethyl-N'-ethyl-N'-phenyl-1,2-ethanediamine ST24031461 2325 RP BDBM50452168 I01-9818 N-Ethyl-N',N'-dimethyl-N-phenylethylenediamine ZINC2012331 AC1L1QOX N'-ethyl-N,N-dimethyl-N'-phenyl-ethane-1,2-diamine SBB061247 1,2-Ethanediamine, N-ethyl-N',N'-dimethyl-N-phenyl- AKOS005306071 EINECS 248-611-3 N,N-Dimethyl-N'-ethyl-N'-phenylethylenediamine ST51047287 2325RP 692E917 Boc-(4-aminomethyl)cyclohexane carboxylic acid LS-68461 N-ETHYL-N-(N',N'-DIMETHYL) AMINOETHYL ANILINE [2-(dimethylamino)ethyl]ethylphenylamine ACT07526 CHEMBL138604 N'-ethyl-N,N-dimethyl-N'-phenylethane-1,2-diamine SCHEMBL8942276 1,2-Ethanediamine, N1-ethyl-N2,N2-dimethyl-N1-phenyl- AX8019914 ETHYLENEDIAMINE, N,N-DIMETHYL-N'-ETHYL-N'-PHENYL- N-(2-(Dimethylamino)ethyl)-N-ethylbenzene amine W-110709 A819162 BRN 2095020 MCULE-7515401483 N1-Ethyl-N2,N2-dimethyl-N1-phenylethane-1,2-diamine [ Show all ]
Inchi Key	FWAWELGQRMERND-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H20N2/c1-4-14(11-10-13(2)3)12-8-6-5-7-9-12/h5-9H,4,10-11H2,1-3H3
PubChem CID	33984
ChEMBL	CHEMBL138604
IUPHAR	N/A
BindingDB	50452168
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	537.0 nM	PMID6581313	BindingDB
Kd	537.03 nM	PMID6581313	ChEMBL

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