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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	5-Chlorotryptamine
Molecular formula	C10H11ClN2
IUPAC name	2-(5-chloro-1H-indol-3-yl)ethanamine
Molecular weight	194.662
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	1.2
Synonyms	5-Chloro-1H-indole-3-ethanamine AB03687 ALBB-004962 HMS1613J03 SCHEMBL626030 ZINC77277 2-(5-Chloro-1H-indol-3-yl)-ethylamine AC1Q3MRZ BBL010651 DTXSID50191073 MCULE-9765462252 ST24039496 2-(5-Chloro-1H-indol-3-yl)ethylamine 6SO AJ-10403 CBMicro_013645 FT-0635010 SBB002535 W-6526 2-(5-Chloranyl-1~{h}-Indol-3-Yl)ethanamine 3764-94-1 5-Chloro-1H-indole-3-ethylamine AB1005638 AS-44802 CHEMBL1288716 I10-0590 SMSF0003286 2-(5-chloro-1H-indol-3-yl)ethan-1-amine 5-Cl-T AC1Q54BY BDBM50331286 EINECS 223-184-6 MolPort-001-791-100 STK386806 1H-Indole-3-ethanamine, 5-chloro- 2-(5-Chloro-1H-indol-3-yl)ethylamine # AB0086136 AKOS000266602 CCG-20517 FVQKQPVVCKOWLM-UHFFFAOYSA-N SC-75924 ZERO/005526 2-(5-chloro-1H-indol-3-yl) ethanamine 5-Chloro-1H-indole 3-ethanamine 5-Chloro-1H-indole-3-ethylamine; 2-(5-Chloro-1H-indol-3-yl)ethanamine AC1L2SXD BB 0242423 CTK4H8554 KB-15163 ST096829 2-(5-chloro-1H-indol-3-yl)ethanamine AC1Q54BZ CB05124 EU-0011875 Oprea1_792077 VI30020 1H-Indole-3-ethanamine,5-chloro- 2-(5-chloroindol-3-yl)ethylamine [ Show all ]
Inchi Key	FVQKQPVVCKOWLM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H11ClN2/c11-8-1-2-10-9(5-8)7(3-4-12)6-13-10/h1-2,5-6,13H,3-4,12H2
PubChem CID	77379
ChEMBL	CHEMBL1288716
IUPHAR	N/A
BindingDB	50331286
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	6.21 nM	PMID8632342	BindingDB

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