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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	MLS-0437175.0001
Molecular formula	C20H18N4
IUPAC name	7-methyl-2,4-bis(4-methylphenyl)pyrazolo[3,4-d]pyridazine
Molecular weight	314.392
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.9
Synonyms	BDBM76071 cid_45917986 7-methyl-2,4-bis(p-tolyl)pyrazolo[3,4-d]pyridazine MolPort-009-015-009 MCULE-9925304846 ZINC36649130 CHEMBL1707517 7-methyl-2,4-bis(4-methylphenyl)pyrazolo[3,4-d]pyridazine [ Show all ]
Inchi Key	FTYRPHUIBDQVCC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18N4/c1-13-4-8-16(9-5-13)20-18-12-24(17-10-6-14(2)7-11-17)23-19(18)15(3)21-22-20/h4-12H,1-3H3
PubChem CID	45917986
ChEMBL	CHEMBL1707517
IUPHAR	N/A
BindingDB	76071
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<32000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
IC50	15400.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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