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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL347593
Molecular formulaC30H47IN2O2
IUPAC nameN-[(1-methylpyridin-1-ium-2-yl)methyl]-N-[(2-tetradecoxyphenyl)methyl]acetamide;iodide
Molecular weight594.622
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogPNone
SynonymsSCHEMBL9306519
2-[[Acetyl[[2- (tetradecyloxy)phenyl]methyl]amino]-methyl]-1-methylpyridinium iodide
2-[[Acetyl[[2-(tetradecyloxy)phenyl]methyl]amino]methyl]-1-methylpyridinium iodide
FSVOTEQDIHWZOI-UHFFFAOYSA-M
Inchi KeyFSVOTEQDIHWZOI-UHFFFAOYSA-M
Inchi IDInChI=1S/C30H47N2O2.HI/c1-4-5-6-7-8-9-10-11-12-13-14-19-24-34-30-22-16-15-20-28(30)25-32(27(2)33)26-29-21-17-18-23-31(29)3;/h15-18,20-23H,4-14,19,24-26H2,1-3H3;1H/q+1;/p-1
PubChem CID9985927
ChEMBLCHEMBL347593
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC5043000.0 nMPMID8496938ChEMBL

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