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GPCR

NamePyroglutamylated RF-amide peptide receptor
SpeciesHomo sapiens (Human)
GeneQRFPR
SynonymQRFP receptor
peptide p518 receptor
Orexigenic neuropeptide QRFP receptor
GPR103
G-protein coupled receptor 103
[ Show all ]
DiseaseN/A
Length431
Amino acid sequenceMQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProtQ96P65
Protein Data BankN/A
GPCR-HGmod modelQ96P65
3D structure modelThis predicted structure model is from GPCR-EXP Q96P65.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5852
IUPHAR333
DrugBankN/A

Ligand

NameCHEMBL2170391
Molecular formulaC40H54N12O8
IUPAC name(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[[2-[(2-aminoacetyl)amino]acetyl]amino]-benzylamino]acetyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide
Molecular weight830.948
Hydrogen bond acceptor11
Hydrogen bond donor11
XlogP-1.4
SynonymsBDBM50396430
Inchi KeyALFOQWAZGGWRER-YDPTYEFTSA-N
Inchi IDInChI=1S/C40H54N12O8/c41-21-33(54)46-22-34(55)51-52(23-28-15-8-3-9-16-28)24-35(56)47-32(25-53)39(60)50-31(20-27-13-6-2-7-14-27)38(59)48-29(17-10-18-45-40(43)44)37(58)49-30(36(42)57)19-26-11-4-1-5-12-26/h1-9,11-16,29-32,53H,10,17-25,41H2,(H2,42,57)(H,46,54)(H,47,56)(H,48,59)(H,49,58)(H,50,60)(H,51,55)(H4,43,44,45)/t29-,30-,31-,32-/m0/s1
PubChem CID71451641
ChEMBLCHEMBL2170391
IUPHARN/A
BindingDB50396430
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC502340.0 nMPMID22800498BindingDB,ChEMBL

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