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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameCHEMBL2431041
Molecular formulaC21H27ClN4O3
IUPAC name2-[4-(2-quinolin-8-yloxyethylamino)butyl]-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione;hydrochloride
Molecular weight418.922
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogPNone
SynonymsN/A
Inchi KeyFHNANKMZHPFQCO-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H26N4O3.ClH/c26-20-17-8-5-14-24(17)21(27)25(20)13-2-1-10-22-12-15-28-18-9-3-6-16-7-4-11-23-19(16)18;/h3-4,6-7,9,11,17,22H,1-2,5,8,10,12-15H2;1H
PubChem CID72712134
ChEMBLCHEMBL2431041
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID24050112ChEMBL

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