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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Rattus norvegicus (Rat)
Gene	Hcar2
Synonym	Protein PUMA-G Nicotinic acid receptor Nic1 Niacr1 niacin receptor 1 HCA2 receptor G-protein coupled receptor HM74A G-protein coupled receptor HM74 G-protein coupled receptor 109A G-protein coupled receptor 109 G protein-coupled receptor 109A PUMAG [ Show all ]
Disease	N/A for non-human GPCRs
Length	360
Amino acid sequence	MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSICYTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVICFLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
UniProt	Q80Z39
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4731
IUPHAR	312
DrugBank	N/A

Ligand

Name	5932-32-1
Molecular formula	C7H8N2O2
IUPAC name	1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid
Molecular weight	152.153
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	0.8
Synonyms	AKOS000441635 CHEMBL128604 EN300-41431 J-503951 Oprea1_415453 SR-01000597146-1 1,4,5,6-TETRAHYDRO-CYCLOPENTAPYRAZOLE-3-CARBOXYLICACID 2,4,5,6-Tetrahydrocyclopentapyrazole-3-carboxylic acid 3-Cyclopentapyrazolecarboxylicacid,2,4,5,6-tetrahydro- AB08420 BAS 01402336 CS-W000372 FCYBBDFUBSEGMX-UHFFFAOYSA-N KB-17091 SBB017927 Y9564 1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid 2H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid AC1Q5UH4 AJ-59343 BDBM50132140 DG-0059 I14-3010 MolPort-000-139-763 SCHEMBL1663622 1,4,5,6-TETRAHYDRO-CYCLOPENTAPYRAZOLE-3-CARBOXYLIC ZINC8996233 2,4,5,6-Tetrahydro-3-cyclopentapyrazolecarboxylic acid 3-Cyclopentapyrazolecarboxylicacid, 2,4,5,6-tetrahydro- AB0041757 ALBB-008812 ChemDiv3_014408 F0452-7554 KB-10477 Q-9094 STK387519 1,4,5,6-tetrahydrocyclopenta [c]pyrazole-3-carboxylic acid 2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylate 4,5,6-trihydrocyclopenta[2,1-d]pyrazole-3-carboxylic acid AB1008866 BB 0219108 CTK1G9218 FT-0646366 KS-000019PA SC-67120 Z-8898 1,4,5,6-Tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid, AldrichCPR 3-cyclopentapyrazolecarboxylic acid, 1,4,5,6-tetrahydro- 884497-47-6 AC1Q748C AKOS000271376 EC-000.1364 IDI1_030206 MolPort-000-823-877 SR-01000597146 1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic acid 2,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic acid 3-Cyclopentapyrazolecarboxylicacid,1,4,5,6-tetrahydro- AB00667834-01 AM804102 CS-D1767 F8880-5931 KB-17090 RP01740 TR-020588 1,4,5,6-tetrahydrocyclopentapyrazole-3-carboxylic acid 2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid AC1LFDON BBL018891 CTK3E6738 HMS1513O20 MCULE-5096372552 SCHEMBL16629837 Z57683732 1H,4H,5H,6H-Cyclopenta[C]Pyrazole-3-Carboxylic Acid 3-Cyclopentapyrazolecarboxylic acid, 2,4,5,6-tetrahydro 932T321 AC1Q748D [ Show all ]
Inchi Key	FCYBBDFUBSEGMX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H8N2O2/c10-7(11)6-4-2-1-3-5(4)8-9-6/h1-3H2,(H,8,9)(H,10,11)
PubChem CID	776416
ChEMBL	CHEMBL128604
IUPHAR	N/A
BindingDB	50132140
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Intrinsic activity	29.0 %	PMID18983141	ChEMBL
Ki	156.0 nM	PMID12930155	BindingDB,ChEMBL

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