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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	5932-32-1
Molecular formula	C7H8N2O2
IUPAC name	1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid
Molecular weight	152.153
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	0.8
Synonyms	2H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid AC1Q5UH4 BAS 01402336 CS-W000372 FCYBBDFUBSEGMX-UHFFFAOYSA-N KB-17091 SBB017927 Y9564 1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid 2,4,5,6-Tetrahydro-3-cyclopentapyrazolecarboxylic acid 3-Cyclopentapyrazolecarboxylicacid, 2,4,5,6-tetrahydro- AB0041757 AJ-59343 BDBM50132140 DG-0059 I14-3010 MolPort-000-139-763 SCHEMBL1663622 1,4,5,6-TETRAHYDRO-CYCLOPENTAPYRAZOLE-3-CARBOXYLIC ZINC8996233 2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylate 4,5,6-trihydrocyclopenta[2,1-d]pyrazole-3-carboxylic acid AB1008866 ALBB-008812 ChemDiv3_014408 F0452-7554 KB-10477 Q-9094 STK387519 1,4,5,6-tetrahydrocyclopenta [c]pyrazole-3-carboxylic acid 1,4,5,6-Tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid, AldrichCPR 3-cyclopentapyrazolecarboxylic acid, 1,4,5,6-tetrahydro- 884497-47-6 AC1Q748C BB 0219108 CTK1G9218 FT-0646366 KS-000019PA SC-67120 Z-8898 2,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic acid 3-Cyclopentapyrazolecarboxylicacid,1,4,5,6-tetrahydro- AB00667834-01 AKOS000271376 EC-000.1364 IDI1_030206 MolPort-000-823-877 SR-01000597146 1,4,5,6-Tetrahydro-cyclopentapyrazole-3-carboxylic acid 2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid AC1LFDON AM804102 CS-D1767 F8880-5931 KB-17090 RP01740 TR-020588 1,4,5,6-tetrahydrocyclopentapyrazole-3-carboxylic acid 1H,4H,5H,6H-Cyclopenta[C]Pyrazole-3-Carboxylic Acid 3-Cyclopentapyrazolecarboxylic acid, 2,4,5,6-tetrahydro 932T321 AC1Q748D BBL018891 CTK3E6738 HMS1513O20 MCULE-5096372552 SCHEMBL16629837 Z57683732 2,4,5,6-Tetrahydrocyclopentapyrazole-3-carboxylic acid 3-Cyclopentapyrazolecarboxylicacid,2,4,5,6-tetrahydro- AB08420 AKOS000441635 CHEMBL128604 EN300-41431 J-503951 Oprea1_415453 SR-01000597146-1 1,4,5,6-TETRAHYDRO-CYCLOPENTAPYRAZOLE-3-CARBOXYLICACID [ Show all ]
Inchi Key	FCYBBDFUBSEGMX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H8N2O2/c10-7(11)6-4-2-1-3-5(4)8-9-6/h1-3H2,(H,8,9)(H,10,11)
PubChem CID	776416
ChEMBL	CHEMBL128604
IUPHAR	N/A
BindingDB	50132140
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	860.0 nM	PMID18665582, PMID17588745	BindingDB,ChEMBL
EC50	10400.0 nM	PMID18665582	BindingDB,ChEMBL
Efficacy	99.0 %	PMID18665582	ChEMBL
Efficacy	106.0 %	PMID18665582	ChEMBL
Ki	156.0 nM	PMID18983141	BindingDB,ChEMBL

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