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GPCR

NamePlatelet-activating factor receptor
SpeciesMus musculus (Mouse)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProtQ62035
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3993
IUPHAR334
DrugBankN/A

Ligand

NameCID 15005335
Molecular formulaC31H28ClN5O3
IUPAC nameethyl 4-(2-chlorophenyl)-6-methyl-2-[4-(2-methylimidazol-1-yl)phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydropyridine-3-carboxylate
Molecular weight554.047
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP5.2
SynonymsN/A
Inchi KeyFCGSNXZAIYCCPV-UHFFFAOYSA-N
Inchi IDInChI=1S/C31H28ClN5O3/c1-4-40-31(39)28-27(23-9-5-6-10-24(23)32)26(30(38)36-25-11-7-8-16-34-25)19(2)35-29(28)21-12-14-22(15-13-21)37-18-17-33-20(37)3/h5-18,27,35H,4H2,1-3H3,(H,34,36,38)
PubChem CID15005335
ChEMBLCHEMBL107159
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
ED5022.0 mg.kg-1PMID1507200ChEMBL

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