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GPCR

Name	Trace amine-associated receptor 1
Species	Homo sapiens (Human)
Gene	TAAR1
Synonym	trace amine receptor 1 TAR1 TaR-1 TA1 receptor TRAR1
Disease	N/A
Length	339
Amino acid sequence	MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
UniProt	Q96RJ0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RJ0
3D structure model	This predicted structure model is from GPCR-EXP Q96RJ0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5857
IUPHAR	364
DrugBank	BE0001044

Ligand

Name	tyramine
Molecular formula	C8H11NO
IUPAC name	4-(2-aminoethyl)phenol
Molecular weight	137.182
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.1
Synonyms	Tyramine base Tyrosamine p-Hydroxy-beta-phenethylamine Phenol, 4-(2-aminoethyl)- SPECTRUM210400 ST24033343 Tenosin-wirkstoff HY-W007606 4-(2-Aminoethyl)-phenol(thyramin) KBio2_004261 4-Hydroxy-beta-phenylethylamine Lopac-T-2879 AB0010532 MLS000079096 alpha-(4-Hydroxyphenyl)-beta-aminoethane NCGC00016011-07 BDBM29135 NCGC00063825-04 bmse000891 NSC249188 CCG-39684 p-Hydroxy-.beta.-phenylethylamine D0C5RZ .beta.-(4-Hydroxyphenyl)ethylamine EINECS 200-115-8 Tox21_110282_1 Tyramine, 99% WLN: Z2R DQ p-Hydroxyphenethylamine SC-15191 Spectrum4_001801 SY002127 GTPL2150 21758-EP2314571A2 InChI=1/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H 4-aminoethylphenol KBioGR_002405 51-67-2 LS-103913 ACMC-1AQH1 NCGC00016011-02 AN-41614 NCGC00016011-10 beta-Hydroxyphenylethylamine NCGC00063825-07 BRD-K53893978-001-03-1 p-(2-aminoethyl)-Phenol CHEMBL11608 DSSTox_CID_23874 2-(4-Hydroxyphenyl)-ethylamine Tyramin Tyramine, Vetec(TM) reagent grade, 99% [3H]-Tyramine P-hydroxy-b-phenethylamine para-Tyramine SMR000059295 SR-01000075365 T-8911 HMS502N20 4-(2-amino-ethyl)-phenol KBio1_000918 4-Hydroxy-b-phenylethylamine KSC269I3J A0302 MFCD00008193 AK-47332 NCGC00016011-05 b-(4-Hydroxyphenyl)ethylamine NCGC00016011-14 bmse000243 NSC 249188 C00483 p-beta-Aminoethylphenol CTK1G9434 (4-hydroxyphenyl)ethylamine DTXSID2043874 2-(p-Hydroxyphenyl)ethylamine Tyramine, 97% UNII-X8ZC7V0OX3 p-Hydroxy-beta-phenylethylamine Phenol, p-(2-aminoethyl)- Spectrum2_000738 ST51037693 Tocosine 21758-EP2281563A1 I01-2032 4-(2-Aminoethyl)phenol KBio2_006829 4-Hydroxyphenethylamine Lopac0_001136 AC1L1KQE MolPort-000-698-914 alpha.-(4-Hydroxyphenyl)-beta-aminoethane NCGC00016011-08 Benzeneethanamine, 4-hydroxy- NCGC00063825-05 BPBio1_001394 Opera_ID_887 CHEBI:15760 DB08841 2-(4'-Hydroxyphenyl)ethylamine FT-0651978 to_000085 Tyramine, analytical standard X8ZC7V0OX3 p-Hydroxyphenylethylamine SCHEMBL4111 Spectrum5_000501 Systogene HMS1923C19 KB-204477 4-Hydroxy phenylethylamine KBioSS_001693 51T672 M-3365 AEF NCGC00016011-03 ANW-31318 NCGC00016011-11 BIDD:ER0507 NCGC00063825-08 BRN 1099914 p-(2-Aminoethyl)phenol cid_5610 DSSTox_GSID_43874 2-(4-hydroxyphenyl)ethanamine Tyramine;4-(2-Amino-ethyl)-phenol [3H]tyramine P-hydroxy-b-phenylethylamine Phenethylamine, p-hydroxy- SPBio_000696 SR-01000075365-5 TC-060462 HSDB 2132 4-(2-aminoethyl)-Phenol KBio2_001693 4-hydroxy-Benzeneethanamine L-Tyramine AB00051887-15 MFCD00149002 AKOS000156022 NCGC00016011-06 BBL027695 NCGC00016011-16 bmse000870 NSC-249188 CAS-51-67-2 p-Hydroxy-.beta.-phenethylamine D01VFT .alpha.-(4-Hydroxyphenyl)-.beta.-aminoethane DZGWFCGJZKJUFP-UHFFFAOYSA-N Tox21_110282 Tyramine, 98%, FG Uteramine p-hydroxy-phenylethylamine RTC-060462 Spectrum3_000693 STK531130 21758-EP2298312A1 IDI1_000918 4-13-00-01788 (Beilstein Handbook Reference) KBio3_001665 4-Hydroxyphenylethylamine LS-103895 AC1Q54AZ NCGC00016011-01 AM20060645 NCGC00016011-09 beta-(4-Hydroxyphenyl)ethylamine NCGC00063825-06 BR-47332 Oprea1_294339 DivK1c_000918 2-(4-hydroxy-phenyl)ethylamine GTPL2148 TRA0098101 Tyramine, free base ZINC2233 p-Tyramine SGCUT00017 Spectrum_001213 T-8910 HMS2235J05 4- (2-aminoethyl)-Phenol KB-62189 4-Hydroxy-.beta.-phenylethylamine KS-00000NMU a-(4-Hydroxyphenyl)-b-aminoethane MCULE-3986856320 AJ-08146 NCGC00016011-04 AS-11671 NCGC00016011-12 Biomol-NT_000075 NINDS_000918 BSPBio_002445 p-.beta.-Aminoethylphenol CS-W007606 DSSTox_RID_80079 2-(4-Hydroxyphenyl)ethylamine [ Show all ]
Inchi Key	DZGWFCGJZKJUFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
PubChem CID	5610
ChEMBL	CHEMBL11608
IUPHAR	2150, 2148
BindingDB	29135
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	177.71 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
EC50	199.526 - 1584.89 nM	PMID11459929, PMID18524885, PMID17038507, PMID19892733, PMID19725810, PMID22073124	IUPHAR
EC50	731.0 nM	PMID18602830	BindingDB,ChEMBL
Emax	91.0 %	PMID18602830	ChEMBL
IC50	881.84 nM	, PubChem BioAssay data set	BindingDB,ChEMBL
Kd	20.0 nM	PMID11459929	IUPHAR
Ki	34.0 nM	PMID11459929	BindingDB

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