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Name | D(1A) dopamine receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | DRD1 |
Synonym | D1 receptor D1A DADR Gpcr15 dopamine D1 receptor [ Show all ] |
Disease | Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder [ Show all ] |
Length | 446 |
Amino acid sequence | MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT |
UniProt | P21728 |
Protein Data Bank | N/A |
GPCR-HGmod model | P21728 |
3D structure model | This predicted structure model is from GPCR-EXP P21728. |
BioLiP | N/A |
Therapeutic Target Database | T22118 |
ChEMBL | CHEMBL2056 |
IUPHAR | 214 |
DrugBank | BE0000020 |
Name | tyramine |
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Molecular formula | C8H11NO |
IUPAC name | 4-(2-aminoethyl)phenol |
Molecular weight | 137.182 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 2 |
XlogP | 1.1 |
Synonyms | KBio2_001693 4-hydroxy-Benzeneethanamine L-Tyramine AB00051887-15 MFCD00149002 [ Show all ] |
Inchi Key | DZGWFCGJZKJUFP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 |
PubChem CID | 5610 |
ChEMBL | CHEMBL11608 |
IUPHAR | 2148, 2150 |
BindingDB | 29135 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 390000.0 nM | PMID9784114 | BindingDB,ChEMBL |
KL | 390000.0 nM | PMID8632409 | ChEMBL |
Log 1/KL | -5.59 - | PMID8632409 | ChEMBL |
Potency | 8199.5 nM | PubChem BioAssay data set | ChEMBL |
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