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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Urotensin-2 receptor
Species	Homo sapiens (Human)
Gene	UTS2R
Synonym	urotensin II receptor UT receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) GPR14 G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	Asthma Diabetic nephropathy Renal failure
Length	389
Amino acid sequence	MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProt	Q9UKP6
Protein Data Bank	N/A
GPCR-HGmod model	Q9UKP6
3D structure model	This predicted structure model is from GPCR-EXP Q9UKP6.
BioLiP	N/A
Therapeutic Target Database	T49072
ChEMBL	CHEMBL3764
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL3104639
Molecular formula	C47H62IN9O10S2
IUPAC name	(2S)-2-[[(4R,7S,10S,13S,16S,19R)-10-(4-aminobutyl)-19-[[(2S)-2-aminopropanoyl]amino]-16-benzyl-7-[(4-hydroxyphenyl)methyl]-13-[(4-iodophenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid
Molecular weight	1104.09
Hydrogen bond acceptor	14
Hydrogen bond donor	11
XlogP	0.7
Synonyms	BDBM50445380 SCHEMBL15686542
Inchi Key	DYSIDVGQAIMCML-ZFCHPTNPSA-N
Inchi ID	InChI=1S/C47H62IN9O10S2/c1-26(2)39(47(66)67)57-46(65)38-25-69-68-24-37(55-40(59)27(3)50)45(64)54-34(21-28-9-5-4-6-10-28)43(62)53-35(22-29-12-16-31(48)17-13-29)42(61)51-33(11-7-8-20-49)41(60)52-36(44(63)56-38)23-30-14-18-32(58)19-15-30/h4-6,9-10,12-19,26-27,33-39,58H,7-8,11,20-25,49-50H2,1-3H3,(H,51,61)(H,52,60)(H,53,62)(H,54,64)(H,55,59)(H,56,63)(H,57,65)(H,66,67)/t27-,33-,34-,35-,36-,37-,38-,39-/m0/s1
PubChem CID	72793526
ChEMBL	CHEMBL3104639
IUPHAR	N/A
BindingDB	50445380
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	57.54 nM	PMID24251366	ChEMBL
IC50	58.0 nM	PMID24251366	BindingDB,ChEMBL

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