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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Homo sapiens (Human)
Gene	HTR1D
Synonym	Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D 5-HT-1D-alpha 5-HT1D 5-HT1D receptor 5-HT1Dalpha 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Gpcr14 HT1DA [ Show all ]
Disease	Acute migraine Epilepsy Migraine headaches Mood disorder Migraine Major depressive disorder Severe mood disorders [ Show all ]
Length	377
Amino acid sequence	MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
UniProt	P28221
Protein Data Bank	N/A
GPCR-HGmod model	P28221
3D structure model	This predicted structure model is from GPCR-EXP P28221.
BioLiP	N/A
Therapeutic Target Database	T11072
ChEMBL	CHEMBL1983
IUPHAR	3
DrugBank	BE0000659

Ligand

Name	CHEMBL103424
Molecular formula	C16H21N3O
IUPAC name	N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]acetamide
Molecular weight	271.364
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.8
Synonyms	AKOS030564993 N-[3-(1-Methylpiperidin-4-yl)-1H-indol-5-yl]acetamide DXVFIKXMKWRGPL-UHFFFAOYSA-N BDBM50130427 SCHEMBL7487827 182563-03-7 CTK0E2792 Acetamide, N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]- N-[3-(1-Methyl-piperidin-4-yl)-1H-indol-5-yl]-acetamide 5-(acetyl)amino-3-(1-methylpiperidin-4-yl)-1H-indole DTXSID90626915 [ Show all ]
Inchi Key	DXVFIKXMKWRGPL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H21N3O/c1-11(20)18-13-3-4-16-14(9-13)15(10-17-16)12-5-7-19(2)8-6-12/h3-4,9-10,12,17H,5-8H2,1-2H3,(H,18,20)
PubChem CID	22611622
ChEMBL	CHEMBL103424
IUPHAR	N/A
BindingDB	50130427
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	150.0 nM	PMID12825944	BindingDB,ChEMBL

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