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Name | Alpha-1A adrenergic receptor |
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Species | Bos taurus (Bovine) |
Gene | ADRA1A |
Synonym | Alpha-1A adrenoceptor Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor |
Disease | N/A for non-human GPCRs |
Length | 466 |
Amino acid sequence | MVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTLHAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACTTARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV |
UniProt | P18130 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4892 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL47471 |
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Molecular formula | C16H18ClN3 |
IUPAC name | 1-benzyl-4-(3-chloropyridin-2-yl)piperazine |
Molecular weight | 287.791 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 3.2 |
Synonyms | BDBM50027026 1-Benzyl-4-(3-chloro-pyridin-2-yl)-piperazine |
Inchi Key | DXBCZLBBXQSAMW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H18ClN3/c17-15-7-4-8-18-16(15)20-11-9-19(10-12-20)13-14-5-2-1-3-6-14/h1-8H,9-13H2 |
PubChem CID | 44292196 |
ChEMBL | CHEMBL47471 |
IUPHAR | N/A |
BindingDB | 50027026 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 700.0 nM | PMID6139479 | BindingDB,ChEMBL |
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