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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	CHEMBL2391452
Molecular formula	C20H18BrN3O3
IUPAC name	N-(4-bromophenyl)-2-[5-(4-methoxyphenyl)-3-methyl-6-oxopyridazin-1-yl]acetamide
Molecular weight	428.286
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.0
Synonyms	BDBM50435891
Inchi Key	AJOBDTHTCCXCQQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18BrN3O3/c1-13-11-18(14-3-9-17(27-2)10-4-14)20(26)24(23-13)12-19(25)22-16-7-5-15(21)6-8-16/h3-11H,12H2,1-2H3,(H,22,25)
PubChem CID	71698446
ChEMBL	CHEMBL2391452
IUPHAR	N/A
BindingDB	50435891
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	11200.0 nM	PMID23685570	ChEMBL
Efficacy	55.0 %	PMID23685570	ChEMBL

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