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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL399651
Molecular formula	C35H33N5O3
IUPAC name	N-[(R)-[4-[(2,4-dimethoxyphenyl)methyl]-5-(2-phenylethyl)-1,2,4-triazol-3-yl]-(1H-indol-3-yl)methyl]benzamide
Molecular weight	571.681
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.8
Synonyms	BDBM50232263 (R)-N-((4-(2,4-dimethoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)(1H-indol-3-yl)methyl)benzamide
Inchi Key	AJMNYVOTXIKAAT-MGBGTMOVSA-N
Inchi ID	InChI=1S/C35H33N5O3/c1-42-27-19-18-26(31(21-27)43-2)23-40-32(20-17-24-11-5-3-6-12-24)38-39-34(40)33(37-35(41)25-13-7-4-8-14-25)29-22-36-30-16-10-9-15-28(29)30/h3-16,18-19,21-22,33,36H,17,20,23H2,1-2H3,(H,37,41)/t33-/m1/s1
PubChem CID	44445620
ChEMBL	CHEMBL399651
IUPHAR	N/A
BindingDB	50232263
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	31.0 %	PMID18193826	ChEMBL
EC50	16.0 nM	PMID18193826	BindingDB,ChEMBL
IC50	11.8 nM	PMID18193826	BindingDB,ChEMBL

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