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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Lysophosphatidic acid receptor 2
Species	Homo sapiens (Human)
Gene	LPAR2
Synonym	endothelial differentiation gene 4, lysophosphatidic acid G-protein-coupled receptor 4 LPA receptor 2 LPA-2 Edg4 Lysophosphatidic acid receptor Edg-4 Pbx4 pre-B-cell leukemia transcription factor 4 LPA2 receptor [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
UniProt	Q9HBW0
Protein Data Bank	N/A
GPCR-HGmod model	Q9HBW0
3D structure model	This predicted structure model is from GPCR-EXP Q9HBW0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3724
IUPHAR	273
DrugBank	N/A

Ligand

Name	CHEMBL270878
Molecular formula	C25H31N5O
IUPAC name	2-cyclopropyl-N-[(2S)-1-[4-(2-methoxyphenyl)piperazin-1-yl]propan-2-yl]quinazolin-4-amine
Molecular weight	417.557
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.5
Synonyms	BDBM50373820
Inchi Key	DVJBHFKQRUZCLO-SFHVURJKSA-N
Inchi ID	InChI=1S/C25H31N5O/c1-18(17-29-13-15-30(16-14-29)22-9-5-6-10-23(22)31-2)26-25-20-7-3-4-8-21(20)27-24(28-25)19-11-12-19/h3-10,18-19H,11-17H2,1-2H3,(H,26,27,28)/t18-/m0/s1
PubChem CID	44454306
ChEMBL	CHEMBL270878
IUPHAR	N/A
BindingDB	50373820
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3200.0 nM	PMID18178086	BindingDB,ChEMBL

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