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Name | Free fatty acid receptor 1 |
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Species | Homo sapiens (Human) |
Gene | FFAR1 |
Synonym | FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor |
Disease | Type 2 diabetes Non-insulin dependent diabetes Diabetes |
Length | 300 |
Amino acid sequence | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK |
UniProt | O14842 |
Protein Data Bank | 5tzy, 5tzr |
GPCR-HGmod model | O14842 |
3D structure model | This structure is from PDB ID 5tzy. |
BioLiP | BL0380462, BL0380463, BL0380464 |
Therapeutic Target Database | T25608 |
ChEMBL | CHEMBL4422 |
IUPHAR | 225 |
DrugBank | BE0000688 |
Name | linolenic acid |
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Molecular formula | C18H30O2 |
IUPAC name | (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid |
Molecular weight | 278.436 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 5.9 |
Synonyms | all-cis-9,12,15-Octadecatrienoic acid NCGC00091058-08 AX8136381 Octadecatrienoic acid, 9,12,15-(Z,Z,Z)- CAS-463-40-1 [ Show all ] |
Inchi Key | DTOSIQBPPRVQHS-PDBXOOCHSA-N |
Inchi ID | InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9- |
PubChem CID | 5280934 |
ChEMBL | CHEMBL8739 |
IUPHAR | 1049 |
BindingDB | 50240347 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 100.0 % | PMID19007110 | ChEMBL |
EC50 | 1995.26 - 25118.9 nM | PMID12496284, PMID12565875, PMID12629551 | IUPHAR |
EC50 | 2884.03 nM | PMID22519963 | BindingDB,ChEMBL |
EC50 | 3000.0 nM | PMID26928019 | BindingDB,ChEMBL |
EC50 | 3162.0 nM | PMID26928019 | BindingDB |
EC50 | 3162.28 nM | PMID26928019 | ChEMBL |
EC50 | 5200.0 nM | PMID19007110 | BindingDB,ChEMBL |
Efficacy | 88.0 % | PMID22519963 | ChEMBL |
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