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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	CHEMBL1770303
Molecular formula	C21H17ClN2O3
IUPAC name	N-[2-anilino-1-(4-chlorophenyl)-2-oxoethyl]-2-hydroxybenzamide
Molecular weight	380.828
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	4.6
Synonyms	BDBM50418358
Inchi Key	AIVTXGMGZMXUBO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H17ClN2O3/c22-15-12-10-14(11-13-15)19(21(27)23-16-6-2-1-3-7-16)24-20(26)17-8-4-5-9-18(17)25/h1-13,19,25H,(H,23,27)(H,24,26)
PubChem CID	54581782
ChEMBL	CHEMBL1770303
IUPHAR	N/A
BindingDB	50418358
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5011.87 nM	PMID21486695	ChEMBL
IC50	5012.0 nM	PMID21486695	BindingDB

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