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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Urotensin-2 receptor
Species	Homo sapiens (Human)
Gene	UTS2R
Synonym	urotensin II receptor UT receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) GPR14 G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	Asthma Diabetic nephropathy Renal failure
Length	389
Amino acid sequence	MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProt	Q9UKP6
Protein Data Bank	N/A
GPCR-HGmod model	Q9UKP6
3D structure model	This predicted structure model is from GPCR-EXP Q9UKP6.
BioLiP	N/A
Therapeutic Target Database	T49072
ChEMBL	CHEMBL3764
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL427632
Molecular formula	C59H80N12O15S2
IUPAC name	(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-3-sulfanylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-3-methylbutanoic acid
Molecular weight	1261.48
Hydrogen bond acceptor	19
Hydrogen bond donor	17
XlogP	-3.6
Synonyms	BDBM50112114 Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val
Inchi Key	DNYPVZDKSSUOES-JVMQEBBWSA-N
Inchi ID	InChI=1S/C59H80N12O15S2/c1-31(2)49(59(85)86)70-56(82)45(30-88)69-52(78)41(25-34-18-20-36(73)21-19-34)64-50(76)39(16-9-10-22-60)63-53(79)42(26-35-28-62-38-15-8-7-14-37(35)38)66-51(77)40(24-33-12-5-4-6-13-33)65-55(81)44(29-87)68-54(80)43(27-47(74)75)67-57(83)46-17-11-23-71(46)58(84)48(61)32(3)72/h4-8,12-15,18-21,28,31-32,39-46,48-49,62,72-73,87-88H,9-11,16-17,22-27,29-30,60-61H2,1-3H3,(H,63,79)(H,64,76)(H,65,81)(H,66,77)(H,67,83)(H,68,80)(H,69,78)(H,70,82)(H,74,75)(H,85,86)/t32-,39+,40+,41+,42+,43+,44+,45+,46-,48+,49+/m1/s1
PubChem CID	44296161
ChEMBL	CHEMBL427632
IUPHAR	N/A
BindingDB	50112114
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.4 nM	PMID11960491	BindingDB,ChEMBL
Emax	103.0 %	PMID11960491	ChEMBL

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