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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Rattus norvegicus (Rat)
Gene	Htr2b
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT-2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F 5-HT2B receptor 5-HT2B 5-HT-2F {ECO:0000303\|PubMed:1331748} Stomach fundus serotonin receptor {ECO:0000303\|PubMed:1505525} [ Show all ]
Disease	N/A for non-human GPCRs
Length	479
Amino acid sequence	MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
UniProt	P30994
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL323
IUPHAR	7
DrugBank	N/A

Ligand

Name	N,N-DIMETHYLTRYPTAMINE
Molecular formula	C12H16N2
IUPAC name	2-(1H-indol-3-yl)-N,N-dimethylethanamine
Molecular weight	188.274
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.5
Synonyms	DEA No. 7435 FT-0667348 L001288 N,N-Dimethyltryptamine (DMT) solution, 1.0 mg/mL in methanol, certified reference material STK370594 (2-Indol-3-ylethyl)dimethylamine 1H-Indole-3-ethanamine,N,N-dimethyl- 3-(2-(dimethylamino)ethyl)-Indole 68677-25-8 CHEBI:28969 DMT (psychogenic) InChI=1/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H MFCD00055989 N-(2-(1H-indol-3-yl)ethyl)-N,N-dimethylamine (ACD/Name 4.0) WUB601BHAA 061D507 2-(1H-Indol-3-yl)-N,N-dimethylethanamine 3-(dimethylaminoethyl)-indole AN-41827 CTK5B3344 EINECS 200-508-4 Indole, 3-[2-(dimethylamino)ethyl]- N,N-Dimethyl-1H-indole-3-ethylamine NSC63795 [2-(1H-indol-3-yl)ethyl]dimethylamine 1H-Indole-3-ethanamine, N,N-dimethyl- (9CI) 2-(1H-indol-3-yl)-N,N-dimethylethylamine BRN 0138259 DIMETHYLTRYPTAMINE GTPL141 LS-82930 N,N-Dimethyltryptamine, >=97% (HPLC) UNII-WUB601BHAA (psychogenic) 2-(1H-indol-3-yl)-ethyl-dimethyl-amine 3-(2-DIMETHYLAMINOETHYL) INDOLE AC1L1LS3 DMULVCHRPCFFGV-UHFFFAOYSA-N Indolalkylamine der N,N-dimethyl-1H-Indole-3-ethanamine NSC 63795 ZINC897457 2-(1H-Indol-3-yl)-N,N-dimethylethanamine # 3-[2- (dimethylamino)ethyl]-Indole AS-47089 D-5500 DB01488 FCH838678 KB-296215 SCHEMBL335710 1H-INDOLE-3-ETHANAMINE,N,N-DIMETHYL 2-(3-Indolyl)ethyldimethylamine 61-50-7 C08302 Dimethyltryptamine(DMT) HSDB 8017 MB00483 N,N-Dimethyltryptamine, free base WLN: T56 BMJ D2N1&1 2-(1H-INDOL-3-YL)-N,N-DIMETHYL-ETHANAMINE 3-(2-Dimethylaminoethyl)indole AKOS005446117 CHEMBL12420 DTXSID60110053 Indole, 3-(2-(dimethylamino)ethyl)- N,N-dimethyl-1H-Indole-3-ethanamine (9CI) NSC-63795 [2-(1H-INDOL-3-YL)-ETHYL]-DIMETHYL-AMINE 1H-Indole-3-ethanamine, N,N-dimethyl- 2-(1H-indol-3-yl)-N,N-dimethylethanamine (ACD/Name 4.0) 3-[2-(dimethylamino)ethyl]indole BDBM50026868 D0K1QS [ Show all ]
Inchi Key	DMULVCHRPCFFGV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3
PubChem CID	6089
ChEMBL	CHEMBL12420
IUPHAR	141
BindingDB	50026868
DrugBank	DB01488
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	1000.0 nM	PMID7086824	BindingDB,ChEMBL

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