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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-1B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1b
Synonym	adrenergic receptor alpha 1B-adrenoceptor alpha 1B-adrenoreceptor adrenergic alpha 1B receptor Alpha-1B adrenoceptor Alpha-1B adrenoreceptor alpha1B-adrenergic receptor alpha1B-adrenoceptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	515
Amino acid sequence	MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
UniProt	P15823
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL315
IUPHAR	23
DrugBank	N/A

Ligand

Name	phenylpropanolamine
Molecular formula	C9H13NO
IUPAC name	2-amino-1-phenylpropan-1-ol
Molecular weight	151.209
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	0.8
Synonyms	(1s, 2r)-(+)-norephedrine 2-Amino-1-phenyl-1-propanol 24136-EP2295406A1 24136-EP2311827A1 alpha-(1-aminoethyl)benzyl alcohol Benzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, (.alpha.S)-rel- Contac IDI1_000795 Norpseudoephedrine, (+)- SCHEMBL98589 (1S,2R)-(+)-Norephedrine 2-amino-1-phenylpropan-1-ol 24136-EP2298776A1 48115-38-4 Benzenemethanol, .alpha.-(1-aminoethyl)-, (R,S)-(.+/-.)- Benzenemethanol, alpha-(1-aminoethyl)- Demazin MCULE-9503580838 Ornade (+)2-Amino-1-phenyl-propan-1-ol 14838-15-4 24136-EP2272825A2 24136-EP2305640A2 AC1L1IYB Benzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, (.alpha.R)- FT-0630600 Norephedrine, (-) Pseudonorephedrine, (+) [cathine, (+)] (1R, 2S)-2-Amino-1-phenyl-propan-1-ol (1S, 2R)-2-Amino-1-phenyl-propan-1-ol 2-Amino-1-phenyl-1-propanol # 24136-EP2295409A1 24136-EP2314590A1 BDBM50022722 Benzenemethanol, .alpha.-[(1S)-1-aminoethyl]-, (.alpha.R)- CTK7J6381 KBio1_000795 NSC-120735 TAVIST-D 2-Amino-2-methyl-1-phenylethanol 24136-EP2298779A1 492A411 Benzenemethanol, .alpha.-(1-aminoethyl)-, [R-(R,S)]- beta-Hydroxy-alpha-methylphenethylamine DivK1c_000795 NINDS_000795 (1 S,2R)-(+)-norephedrine 2-Amino-1-hydroxy-1-phenylpropane 24136-EP2281815A1 24136-EP2308839A1 AKOS015891154 Benzenemethanol, .alpha.-[(1R)-1-aminoethyl]-, (.alpha.R)-rel- CHEMBL61006 I01-9308 Norephedrine, (.+/-.)- Pseudonorephedrine, (-) [cathine, (-)] (1S, 2R )-(+)-norephedrine (1S, 2S)-2-Amino-1-phenyl-propan-1-ol 2-Amino-1-phenyl-propan-1-ol 24136-EP2298772A1 37577-28-9 Benzenemethanol, .alpha.-(1-aminoethyl)- Benzenemethanol, .alpha.-[(1S)-1-aminoethyl]-, (.alpha.S)- D-(+)-Norephedrine L001077 NSC120735 1-phenyl-2-aminopropanol 24136-EP2269989A1 24136-EP2301933A1 Benzenemethanol, .alpha.-(1-aminoethyl)-, [S-(R,R)]- CHEMBL136560 DLNKOYKMWOXYQA-UHFFFAOYSA-N Norephedrine, (+) Phenylpropanolamine (mixed isomers) (1R, 2R)-2-Amino-1-phenyl-propan-1-ol [ Show all ]
Inchi Key	DLNKOYKMWOXYQA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3
PubChem CID	4786
ChEMBL	CHEMBL61006
IUPHAR	N/A
BindingDB	50022722
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	280000.0 nM	PMID12238918	BindingDB
EC50	281838.0 nM	Med Chem Res, (2004) 13:3:134	ChEMBL
Efficacy	34.0 %	PMID15163201, Med Chem Res, (2004) 13:3:134	ChEMBL
pD2	3.55 -	PMID15163201	ChEMBL

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