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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Rattus norvegicus (Rat)
Gene	Htr4
Synonym	5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	406
Amino acid sequence	MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProt	Q62758
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4317
IUPHAR	9
DrugBank	N/A

Ligand

Name	CHEMBL48698
Molecular formula	C15H22ClN3O3
IUPAC name	2-piperidin-1-ylethyl N-(4-amino-5-chloro-2-methoxyphenyl)carbamate
Molecular weight	327.809
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.3
Synonyms	(4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid 2-piperidin-1-yl-ethyl ester (2-Methoxy-4-amino-5-chlorophenyl)carbamic acid 2-piperidinoethyl ester BDBM50058190
Inchi Key	DKKJQTGVQFSWFS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H22ClN3O3/c1-21-14-10-12(17)11(16)9-13(14)18-15(20)22-8-7-19-5-3-2-4-6-19/h9-10H,2-8,17H2,1H3,(H,18,20)
PubChem CID	10568248
ChEMBL	CHEMBL48698
IUPHAR	N/A
BindingDB	50058190
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	39.0 nM	PMID9171886	BindingDB,ChEMBL

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