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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Platelet-activating factor receptor
Species	Mus musculus (Mouse)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProt	Q62035
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3993
IUPHAR	334
DrugBank	N/A

Ligand

Name	CHEMBL100190
Molecular formula	C25H29N5O2
IUPAC name	2-(2-methylpyridin-3-yl)-2-[4-[3-(2-oxopyrrolidin-1-yl)-3-phenylpropanoyl]piperazin-1-yl]acetonitrile
Molecular weight	431.54
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	1.4
Synonyms	SCHEMBL9574990 (2-Methyl-pyridin-3-yl)-{4-[3-(2-oxo-pyrrolidin-1-yl)-3-phenyl-propionyl]-piperazin-1-yl}-acetonitrile [4-[3-Phenyl-1-oxo-3-(2-oxopyrrolidin-1-yl)propyl]piperazin-1-yl](2-methyl-3-pyridyl)acetonitrile BDBM50045967
Inchi Key	DJFOZVOJJFSISR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H29N5O2/c1-19-21(9-5-11-27-19)23(18-26)28-13-15-29(16-14-28)25(32)17-22(20-7-3-2-4-8-20)30-12-6-10-24(30)31/h2-5,7-9,11,22-23H,6,10,12-17H2,1H3
PubChem CID	10365462
ChEMBL	CHEMBL100190
IUPHAR	N/A
BindingDB	50045967
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ID50	0.13 mg.kg-1	PMID8411016	ChEMBL

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