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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Rattus norvegicus (Rat)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProt	P14842
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL322
IUPHAR	6
DrugBank	N/A

Ligand

Name	2,3-Dimethoxyamphetamine
Molecular formula	C11H17NO2
IUPAC name	1-(2,3-dimethoxyphenyl)propan-2-amine
Molecular weight	195.262
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.5
Synonyms	1-(2,3-Dimethoxyphenyl)-2-propanamine # BDBM50091080 SCHEMBL729393 (+/-)2-(2,3-Dimethoxy-phenyl)-1-methyl-ethylamine AKOS000152288 DHLWJXGSZDJWKK-UHFFFAOYSA-N 1-(2,3-dimethoxyphenyl)propan-2-amine Benzeneethanamine, 2,3-dimethoxy-alpha-methyl- CHEMBL280855 1-(2,3-Dimethoxyphenyl)-2-propanamine AKOS022488574 Dimethoxyamphetamine 15402-81-0 Benzeneethanamine,2,3-dimethoxy-.alpha.-methyl- AC1L3LPJ CTK6J4170 [ Show all ]
Inchi Key	DHLWJXGSZDJWKK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C11H17NO2/c1-8(12)7-9-5-4-6-10(13-2)11(9)14-3/h4-6,8H,7,12H2,1-3H3
PubChem CID	91255
ChEMBL	CHEMBL280855
IUPHAR	N/A
BindingDB	50091080
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4280.0 nM	PMID10956215	BindingDB
Ki	4280.0 nM	PMID10956215	ChEMBL

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