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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Homo sapiens (Human)
Gene	HTR2A
Synonym	5-HT-2 serotonin receptor 2A serotonin 5HT-2 receptor 5-HT-2A 5-HT2A receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5Ht-2 'D' receptor [ Show all ]
Disease	Depression Unspecified Diabetes Erythropoietic porphyria Fibromyalgia Sleep disorders Schizophrenia Psychiatric disorder Pancreatitis Mood disorder Migraine Hemorrhoids Glaucoma Central nervous system disease Cardiovascular disorder Addiction Schizophrenia; Sleep maintenance insomnia Alcohol use disorders Anxiety disorder [ Show all ]
Length	471
Amino acid sequence	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
UniProt	P28223
Protein Data Bank	6a93, 6a94
GPCR-HGmod model	P28223
3D structure model	This structure is from PDB ID 6a93.
BioLiP	BL0441025,BL0441028, BL0441031, BL0441030,BL0441033, BL0441029,BL0441032, BL0441026, BL0441024,BL0441027
Therapeutic Target Database	T32060
ChEMBL	CHEMBL224
IUPHAR	6
DrugBank	BE0000451

Ligand

Name	cinnarizine
Molecular formula	C26H28N2
IUPAC name	1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine
Molecular weight	368.524
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	5.8
Synonyms	HMS3712H18 AC1LU5GC Labyrin Artate MFCD00056037 C26H28N2 N-Benzhydryl-N'-cinnamylpiperazine CHEBI:31403 NCGC00021488-03 Cinazyn QTL1_000023 Piperazine, (E)- Cinnarizine, powder SCHEMBL44957 D01295 SR-01000003093 1-Benzhydryl-4-cinnamylpiperazin DSSTox_GSID_22821 Stugeron\|Dimitronal\|Stutgin\|Cinarizine 1-trans-Cinnamyl-4-diphenylmethylpiperazine Giganten Tox21_500314 298-57-7 W-106970 4-((2E)-3-phenylprop-2-enyl)-1-(diphenylmethyl)piperazine Ixertol AOB5321 Lopac0_000314 BRD-K07220430-001-03-6 MLS000028498 CCG-204409 NCGC00018187-04 cid_1547484 NCGC00260999-01 R-1575 Prestwick2_000278 Cinnarizinum Senoger 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine Denapol ST069378 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine EBD32904 Stutgeron 1412-EP2280008A2 Hilactan HMS2234B20 ZINC19632891 7002-58-6 (di-hydrochloride) KS-5155 Apotomin Marisan BSPBio_000156 MLS002222167 Cero-Aterin NCGC00018187-07 Cinarizina [INN-Spanish] Prestwick_115 Olamin Cinnarizine [USAN:INN:BAN:JAN] SBB057016 Corathiem SMR000058307 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine Dimitronal Stugeron 1-Cinnamyl-4-(diphenylmethyl)piperazine EU-0100314 Tox21_110109 1412-EP2305219A1 298C577 HY-B1090 AKOS002134299 Lazeta BDBM50017657 Midronal Carecin NCGC00015246-02 NCGC00021488-04 Cinnacet R 1575 Piperazine, 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)- Cinnarizine-d8 SCHEMBL44958 (E)-1-Benzhydryl-4-cinnamylpiperazine D0Q3YO SR-01000003093-2 1-Benzhydryl-4-cinnamylpiperazine DSSTox_RID_76744 Stunarone 1-[di(phenyl)methyl]-4-(3-phenylprop-2-enyl)piperazine Glanil UNII-3DI2E1X18L W-110442 J10228 Aplactan LP00314 BRD-K74927006-001-01-2 MLS001148649 Cerebolan NCGC00018187-05 Cinaperazine NSC-290687 Cinnarizine (JAN/USAN/INN) R-516 Cinnarizinum [INN-Latin] Sepan 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine DERZBLKQOCDDDZ-JLHYYAGUSA-N STK216257 1-benzhydryl-4-[(E)-cinnamyl]piperazine Eglen Stutgin 1412-EP2298764A1 HMS1568H18 HMS3260P10 A820077 L001227 ARONIS27007 MD 516 C 5270 MolPort-002-056-760 CHEBI:131176 NCGC00018187-09 Cinarizine Processine Opera_ID_1776 Cinnarizine, European Pharmacopoeia (EP) Reference Standard SC-14096 CS-4656 Spaderizine 1-(diphenylmethyl)-4-[(E)-3-phenylprop-2-enyl]piperazine DSSTox_CID_2821 Stugeron (TN) 1-Cinnamyl-4-diphenylmethylpiperazine Folcodal Tox21_110109_1 16699-20-0 3DI2E1X18L I01-3582 AN-25314 Libotasin BPBio1_000172 Mitronal CAS-298-57-7 NCGC00018187-03 CHEMBL43064 NCGC00021488-05 Cinnageron R 516 Piperazine, 1-cinnamyl-4-(diphenylmethyl)- Cinnarizine; 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine Sedatromin 1-(Diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)piperazine SR-01000003093-6 1-benzhydryl-4-[(2E)-3-phenylprop-2-enyl]piperazine DTXSID3022821 Stunarone (TN) 1412-EP2275420A1 GTPL9072 Votegol HMS2095H18 Zepamol 516 MD Katoseran Aplexal LS-111394 BRN 0626121 MLS002207295 Cerepar NCGC00018187-06 Cinarizina Prestwick3_000278 NSC290687 Cinnarizine Stugeron S4727 component of Emesazine (Salt/Mix) Siptazin 1-(diphenylmethyl)-4-(3-phenylprop-2-en-1-yl)piperazine Dimitron Stonoron 1-Benzhydryl-4-[3-phenyl-2-propenyl]piperazine # EINECS 206-064-8 Toliman 1412-EP2298765A1 [ Show all ]
Inchi Key	DERZBLKQOCDDDZ-JLHYYAGUSA-N
Inchi ID	InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+
PubChem CID	1547484
ChEMBL	CHEMBL43064
IUPHAR	N/A
BindingDB	50017657
DrugBank	DB00568
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	360.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	103.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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