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GPCR

NameAlpha-2A adrenergic receptor
SpeciesBos taurus (Bovine)
GeneADRA2A
SynonymAlpha-2A adrenoceptor
Alpha-2A adrenoreceptor
Alpha-2AAR
Alpha-2D adrenergic receptor
DiseaseN/A for non-human GPCRs
Length452
Amino acid sequenceMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRGRSGQPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDATAAELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPAGAGADALDLEESSSSEHAERPPGSRRSERGPRAKGKARASQVKPGDSLPRRGPGATGLGAPTAGPAEERSGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCPVPPTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProtQ28838
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4744
IUPHARN/A
DrugBankN/A

Ligand

NameCID 44350012
Molecular formulaC17H25N5O4
IUPAC name(Z)-hex-3-enedioic acid;3-methyl-8-piperazin-1-yl-2,3-dihydroimidazo[1,2-a]pyrazine
Molecular weight363.418
Hydrogen bond acceptor7
Hydrogen bond donor3
XlogPNone
SynonymsN/A
Inchi KeyDDLRSDUTHPWRGU-BTJKTKAUSA-N
Inchi IDInChI=1S/C11H17N5.C6H8O4/c1-9-8-14-11-10(13-4-7-16(9)11)15-5-2-12-3-6-15;7-5(8)3-1-2-4-6(9)10/h4,7,9,12H,2-3,5-6,8H2,1H3;1-2H,3-4H2,(H,7,8)(H,9,10)/b;2-1-
PubChem CID44350012
ChEMBLCHEMBL126394
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki1600.0 nMPMID1359141ChEMBL

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