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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	2-N-(4-aminophenyl)benzene-1,2-diamine
Molecular formula	C12H13N3
IUPAC name	2-N-(4-aminophenyl)benzene-1,2-diamine
Molecular weight	199.257
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	2.1
Synonyms	CTK1D1044 MolPort-003-719-892 UNM000002426702 AKOS001588170 EU-0000264 Oprea1_462403 CHEMBL1597827 MLS000084680 SR-01000390472 1,2-Benzenediamine, N-(4-aminophenyl)- DDLOISMWPUUWPL-UHFFFAOYSA-N N-(4-aminophenyl)benzene-1,2-diamine ZINC262111 4907-43-1 BDBM37692 HMS2436I04 SCHEMBL1636651 (2-amino-phenyl)-(4-amino-phenyl)-amine cid_774866 MLS000100681 SR-01000390472-1 DTXSID60354490 N2-(4-aminophenyl)benzene-1,2-diamine AC1LGOKH MCULE-3534101562 SMR000015718 (2-aminophenyl)-(4-aminophenyl)amine [ Show all ]
Inchi Key	DDLOISMWPUUWPL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H13N3/c13-9-5-7-10(8-6-9)15-12-4-2-1-3-11(12)14/h1-8,15H,13-14H2
PubChem CID	774866
ChEMBL	CHEMBL1597827
IUPHAR	N/A
BindingDB	37692
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<43700.0 nM	N/A	BindingDB
Ki	<66700.0 nM	PubChem BioAssay data set	ChEMBL

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