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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameSCHEMBL17418762
Molecular formulaC31H35FN2O5
IUPAC name(3S)-3-[3-[[6-cycloheptyloxy-5-(2-fluoro-5-methoxyphenyl)pyrazin-2-yl]methoxy]phenyl]-3-cyclopropylpropanoic acid
Molecular weight534.628
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP6.3
SynonymsUS9688642, 27
(3S)-3-(3-((6-(Cycloheptyloxy)-5-(2-fluoro-5-methoxyphenyl)pyrazin-2-yl)methoxy)phenyl)-3-cyclopropylpropanoic acid
NUIAFSGPWFFSBS-SANMLTNESA-N
BDBM168157
Inchi KeyNUIAFSGPWFFSBS-SANMLTNESA-N
Inchi IDInChI=1S/C31H35FN2O5/c1-37-24-13-14-28(32)27(16-24)30-31(39-23-8-4-2-3-5-9-23)34-22(18-33-30)19-38-25-10-6-7-21(15-25)26(17-29(35)36)20-11-12-20/h6-7,10,13-16,18,20,23,26H,2-5,8-9,11-12,17,19H2,1H3,(H,35,36)/t26-/m0/s1
PubChem CID118645543
ChEMBLN/A
IUPHARN/A
BindingDB168157
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC5024.0 nMN/ABindingDB

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