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GPCR

NameFree fatty acid receptor 1
SpeciesRattus norvegicus (Rat)
GeneFfar1
SynonymFFA1 receptor
FFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
DiseaseN/A for non-human GPCRs
Length300
Amino acid sequenceMDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK
UniProtQ8K3T4
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1795180
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL17419029
Molecular formulaC31H29FN2O4
IUPAC name(3S)-3-cyclopropyl-3-[3-[[5-(2-fluoro-5-methoxyphenyl)-6-(3-methylphenyl)pyrazin-2-yl]methoxy]phenyl]propanoic acid
Molecular weight512.581
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP5.7
SynonymsBDBM168169
US9688642, 20
(S)-3-Cyclopropyl-3-(3-((5-(2-fluoro-5-methoxyphenyl)-6-(m-tolyl)pyrazin-2-yl)methoxy)phenyl)propanoic acid
NTFBDXAQEWSVHG-SANMLTNESA-N
Inchi KeyNTFBDXAQEWSVHG-SANMLTNESA-N
Inchi IDInChI=1S/C31H29FN2O4/c1-19-5-3-7-22(13-19)30-31(27-15-24(37-2)11-12-28(27)32)33-17-23(34-30)18-38-25-8-4-6-21(14-25)26(16-29(35)36)20-9-10-20/h3-8,11-15,17,20,26H,9-10,16,18H2,1-2H3,(H,35,36)/t26-/m0/s1
PubChem CID118645781
ChEMBLN/A
IUPHARN/A
BindingDB168169
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC5084.0 nMN/ABindingDB

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