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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Free fatty acid receptor 1
Species	Rattus norvegicus (Rat)
Gene	Ffar1
Synonym	FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40
Disease	N/A for non-human GPCRs
Length	300
Amino acid sequence	MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK
UniProt	Q8K3T4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1795180
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL17418582
Molecular formula	C26H28FN3O4
IUPAC name	(3S)-3-cyclopropyl-3-[3-[[6-(dimethylamino)-5-(2-fluoro-5-methoxyphenyl)pyrazin-2-yl]methoxy]phenyl]propanoic acid
Molecular weight	465.525
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	4.1
Synonyms	BDBM168176 US9688642, 38 (3S)-3-Cyclopropyl-3-(3-((6-(dimethylamino)-5-(2-fluoro-5-methoxyphenyl)pyrazin-2-yl)methoxy)phenyl)propanoic acid NJQYNMKDHSNQIC-NRFANRHFSA-N
Inchi Key	NJQYNMKDHSNQIC-NRFANRHFSA-N
Inchi ID	InChI=1S/C26H28FN3O4/c1-30(2)26-25(22-12-19(33-3)9-10-23(22)27)28-14-18(29-26)15-34-20-6-4-5-17(11-20)21(13-24(31)32)16-7-8-16/h4-6,9-12,14,16,21H,7-8,13,15H2,1-3H3,(H,31,32)/t21-/m0/s1
PubChem CID	118645385
ChEMBL	N/A
IUPHAR	N/A
BindingDB	168176
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	397.0 nM	N/A	BindingDB

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